Strontium-89 (Sr), a bone-seeking radiopharmaceutical, has been used successfully in recent trials to palliate bone pain secondary to metastatic disease. The use of this beta emitter in systemic radionuclide therapy should become an integral part in the management of many patients with metastatic disease to the bone. Intravenous Sr may be used in conjunction with standard chemotherapy and exter...

This paper evaluates and generalises state-of-the-art approaches for modelling short duration liquid discharges of radionuclides ((3)H, (14)C, (60)Co, (134)Cs, (137)Cs, (65)Zn, (89)Sr, (90)Sr, (125)I, (131)I, (241)Am, isotopes of Pu and U) to rivers. An advection-dispersion model was parameterised and used to predict the concentrations of radionuclides in the river environment, i.e. in river wa...

When assessing hand injuries, the history should focus on the mechanism of the injury, hand position at the time of the insult, perceived resultant functional impairment, and the time elapsed since the injury. Some mechanisms yield classic injury patterns, such as the jersey finger and mallet finger. Other injury patterns are known for their poor outcomes, such as fight bites or high-pressure i...

background: one area of nanoscience deals with nanoscopic interactions between nanostructured materials and biological systems. to elucidate the effects of the substrate surface morphology and viscoelasticity on cell proliferation, fractal analysis was performed on endothelial cells cultured on nanocomposite samples based on silicone rubber (sr) and various concentrations of organomodified nano...

This paper investigates politically connected firms in Germany. With the introduction of a new transparency law in 2007, information on additional income sources for all members of the German parliament became publicly available. We find that members of the conservative party (CDU/CSU) and the liberal party (FDP) are more likely to work for firms than members of left-wing parties (SPD and The L...

Abstract Background Patients with hypertrophic cardiomyopathy (HCM) are at increased risk of atrial fibrillation (AF) and stroke, especially an advanced disease stage. To date, however, the incidence factors associated cardioembolic events in HCM patients without AF remain unresolved. Purpose determine stroke whom cardiac rhythm was monitored a implantable electronic device (CIED). The associat...

Ca release from cardiac sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) is regulated by dyadic cleft [Ca ] and intra-SR free [Ca ] ([Ca ]SR). Robust SR Ca 2 release termination is important for stable excitation–contraction coupling, and partial [Ca ]SR depletion may contribute to release termination. Here, we investigated the regulation of SR Ca release termination of spontaneous lo...

This article analyses a game where players sequentially choose either to become insiders and pick one of fi nitely many locations or to remain outsiders. They will only become insiders if a minimum distance to the next player can be assured; their secondary objective is to maximise the minimal distance to other players. This is illustrated by considering the strategic behaviour of men choosing ...