the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...

Spray drying is gaining traction in the pharmaceutical industry as one of processing methods choice for manufacture solid dosage forms intended pulmonary, oral, and parenteral delivery. This process particularly advantageous because its ability to produce engineered particles with improved efficacy stability by combining active ingredients or biologics appropriate excipients. Moreover, due high...

This work aimed to establish an integrated approach investigate the total phenolic content and antioxidant activities of dried skim camel cow milk their fractions. The fractions were obtained by acid or enzymatic coagulation followed spray drying (inlet temperature/outlet temperature: 125 ± 2 °C/90 °C) freeze (−50 °C, 0.05 mbar) coupled not gamma irradiation (at 5, 11, 22 kGy). results showed t...

aflatoxin m1 (afm1) is an important mycotoxin frequently found in milk and dairy products. dairy products and colostrum may be contaminated by aflatoxin m1 when dairy cattle have fed with aflatoxin b1-contaminated feeds. this study was undertaken in a dairy farm around tehran province to determine the presence and level of aflatoxin m1 (afm1) in spray dried and lyophilized colostrum samples. in...