In Sprague-Dawley rats, fatty acid synthase (FAS) activity is suppressed by dietary fat. To test the hypothesis that a defect in regulation of de novo fatty acid synthesis exists in massive obesity, we investigated the effect of diet on FAS mRNA levels in genetically obese JCR:LA-corpulent (cp) rats. We also determined levels of mRNA encoding adipsin, a fat cell-derived protein possibly associa...

In seeking an animal model of age-associated changes in the male reproductive tract, we examined the effects of age on the health and testicular steroidogenic activity of the Brown Norway rat, with comparisons made to the Sprague-Dawley rat. When perfused in vitro under conditions of maximally stimulating luteinizing hormone significant age-associated reductions were seen in testosterone produc...

The aim of this study was to determine the range and incidences of spontaneous microscopic lesions of the pituitary gland in control Han-Wistar and Sprague-Dawley rats and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the pituitary gland were generally uncommon,...

In this paper we study 3-Euclid, a modification of the game Euclid to three dimensions. In 3-Euclid, a position is a triplet of positive integers, written as (a, b, c). A legal move is to replace the current position with one in which any integer has been reduced by an integral multiple of some other integer. The only restriction on this subtraction is that the result must stay positive.We solv...

The present study investigated the role of the renal nerves in mediating the cardiovascular and renal responses produced by the central administration of the opioid-like peptide orphanin FQ/nociceptin (OFQ/N) in conscious Sprague-Dawley rats. In conscious rats, OFQ/N (10 μg icv) produced a transient bradycardia and hypotension (nadir 20 min). Although renal sympathetic nerve activity (RSNA) ini...

OBJECTIVE This study aimed to investigate the effect of masticatory functional changes on the lateral view morphology of the mandible in adult rats. DESIGN Sixty 21-day-old male Sprague-Dawley rats were divided into two groups. Sixteen received ordinary (hard) food during the whole experimental period (normal group). The remaining 44 received a soft diet during 21 weeks to develop a hypofunct...

Extremely low-frequency magnetic field (ELF-MF) has been suggested to influence the cognitive capability but this should be dynamically evaluated in a longitudinal study. Previous training can affect performance, but the influence under magnetic field is unclear. This study aims to evaluate the effects of previous training and ELF-MF exposure on learning and memory using the Morris water maze (...

Unrestrained male Sprague-Dawley rats were infused for seven days with a low (2.45 micrograms/hr) or high (9.81 micrograms/hr) concentration of E. coli lipopolysaccharide (LPS). Compared to control (saline-infused) rats, food intake in the LPS-infused rats remained depressed for the entire infusion period. Despite this long-term suppression of food intake, fever was observed only during the day...

We measured renal, splenogastric, and lumbar multiunit sympathetic activities in chloralose-anesthetized, paralyzed, and artificially respired Sprague-Dawley rats. Acute spinal transection reduced arterial pressure and lumbar sympathetic activity. However, renal and splenogastric activities were doubled after transection. We conclude that spinal systems exist in the rat that are capable of main...

Histocompatible Fischer 344 and Lewis rats have been shown to differ on a wide variety of behavioral, chemical, and molecular measures. This investigation aimed to clarify strain differences in unconditioned motor behavior with respect to the amount and patterns of movements. Twenty female Fischer 344, Lewis, and Sprague-Dawley were tested in the Behavioral Pattern Monitor for 30 min. The locom...