Isoimmunity to a methylcholanthrene-indueed fibrosarcoma and to a spontaneous breast adenocarcinoma was induced in female O3H/HeX mice. Circulating antitumor antibodies spé cifie for the particular immunizing tumor were detected in the immune mice. These antibodies did not appear until the primary tumors were surgically removed. Measurable amounts of anti body could be detected as long as 3.5 ...

In a study of the development of leiomyomas in female rats with an endocrine imbalance (3) a malignant tumor which had many metastases was found in one of the animals. This tumor was iden tified as a uterine adenocarcinoma. Since such a tumor had not previously been seen in our colony, it was thought that the endocrine imbalance might have been a contributing factor. Bullock and Cur tis (1) hav...

Isolated skeletal metastasis of endometrial carcinoma is very unusual. Herein, we report a 62-year-old woman diagnosed as FIGO stage IC, grade I, endometrial carcinoma who was found to have isolated femur and tibia metastases just after completing local radiotherapy. Incisional biopsy revealed metastatic adenocarcinoma. Following radiotherapy, medroxyprogesterone acetate and zoledronic acid was...

Isoimmunity to a methylcholanthrene-indueed fibrosarcoma and to a spontaneous breast adenocarcinoma was induced in female O3H/HeX mice. Circulating antitumor antibodies spé cifie for the particular immunizing tumor were detected in the immune mice. These antibodies did not appear until the primary tumors were surgically removed. Measurable amounts of anti body could be detected as long as 3.5 ...

Radical prostatectomy is a well known treatment for prostate cancer, with a low incidence of early postoperative complications. Our case is a 54 year old patient diagnosed with prostate adenocarcinoma, Gleason score 3+3=6 with 8 ng/ml of PSA, treated by retropubic prostatectomy, who suffered spontaneous perforation of the duodenum. We chose a conservative management, resolved in 30 days. When d...

A spontaneous prostatic adenocarcinoma (R-3327) of a Copenhagen rat has been maintained for 14 generations by s.c. transplantations to Copenhagen and Fi hybrid hosts. The tumor remains histologically a well-differentiated ade nocarcinoma. In order to study the role of gonadal hor mones in this system, tumor expiants were inoculated to intact males, castrated males, and intact females, and the g...

Harderian gland tumors are extremely rare in female F344 rats. An expansive enlarging lesion of the Harderian gland with compression, distortion and invasion of the surrounding muscle was found in a 110-week-old female F344/DuCrj rat, which was diagnosed as a Harderian gland adenocarcinoma. Epithelial growth patterns such as glandular, lobular, papillary and duct forming patterns were exhibited...

Grafts of a transplantable mouse sarcoma designated as No. 180, and those of an attenuated strain of a more malignant Sarcoma S/37, treated with testicle extract, either fail to grow on inoculation or result in tumors of a lower growth rate than the controls. Autografts of spontaneous mouse tumors so treated show little if any effect, while the Bashford adenocarcinoma and the unattenuated S/37 ...

A spontaneous prostatic adenocarcinoma (R-3327) of a Copenhagen rat has been maintained for 14 generations by s.c. transplantations to Copenhagen and Fi hybrid hosts. The tumor remains histologically a well-differentiated ade nocarcinoma. In order to study the role of gonadal hor mones in this system, tumor expiants were inoculated to intact males, castrated males, and intact females, and the g...

The high failure rate of late-stage human clinical trials, particularly in oncology, predicates the need for improved translation of preclinical data from mouse tumor models into clinical predictions. Genetically engineered mouse models (GEMM) may fulfill this need, because they mimic spontaneous and autochthonous disease progression. Using oncogenic Kras-driven GEMMs of lung and pancreatic ade...