© 2014 The Authors. doi: 10.2340/00015555-1641 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Spitz naevus was first described by Sophie Spitz in 1948 (1). It is a variant of benign melanocytic naevus composed of spindled and epithelioid melanocytes, found predominantly in children and adolescents. A number of histopathological variants have been reported, such as desmopl...

Dysplastic nevus is an acquired or hereditary nevus that clinically seems atypical and pathohistologically dysplastic. The term of dysplastic nevus has changed through history and even until now the dermatologists and pathologists have not found the same conclusion for name and definition of dysplastic nevus. Epidemiology of dysplastic nevus is different depending on geographic lattitude, being...

Dermoscopy is a practical, non-invasive tool that can be used to distinguish tinea nigra from other lesions appear macroscopically similar, including acral nevus. Under dermoscopy, presents with pattern of spiculated gray-brown pigment deposition, whereas nevus most often as brown deposition in parallel furrow pattern.

Reed nevus (pigmented spindle cell nevus) is a nevus with the histopathological features of abundant melanin, monomorphic spindle-epithelioid melanocytes, spindle cell nests confined within the epidermis and papillary dermis, and occasional upward interepidermal progression of melanocytes. Here, we reported an unusual case of Reed nevus in an 11-month-old Japanese male infant. Infantile Reed ne...

Melanocytic nevus is the benign proliferation of melanocytes. The most common location of melanocytic nevus is the skin of the extremities; however, there are few case reports of melanocytic nevus at the rectal mucosa. No prior case of malignant melanoma from melanocytic nevus at the rectal mucosa has been reported; therefore, it is unclear whether resection should be performed or close observa...

Activation of the Drosophila EGF receptor requires the transmembrane TGF-alpha-like ligand Spitz. Recent studies have shed new light on the role of two transmembrane proteins, Star and Rhomboid, in the presentation and subsequent proteolytic processing of Spitz.

Epidermal growth factor receptor (EGFR) ligands undergo a complex series of processing events during their maturation to active signaling proteins. Like its mammalian homologs, the predominant Drosophila EGFR ligand Spitz is produced as a transmembrane pro-protein. In the secretory pathway, Spitz is cleaved within its transmembrane domain to release the extracellular signaling domain. This doma...

The current study presents a rare case of intradermal melanocytic nevus with lymphatic nevus cell embolus. A 26-year-old male presented with a slowly enlarging, pigmented nodule on the back, measuring 1 cm in diameter. Histological observations of the lesion were typical of an intradermal melanocytic nevus. The most notable feature of this nevus, however, was an aggregate of nevus cells within ...

OBJECTIVES To describe the different vascular structures seen by dermoscopy and to evaluate their association with various melanocytic and nonmelanocytic skin tumors in a large series of cases. DESIGN Digital dermoscopic images of the lesions were evaluated for the presence of various morphologic types of vessels. SETTING Specialized university clinic. PATIENTS From a larger database, 531...

A malignant transformation is known to occur in many nevi such as a sebaceous nevus or a basal cell nevus, but a verrucous epidermal nevus has only rarely been associated with neoplastic changes. Keratoacanthoma, multifocal papillary apocrine adenoma, multiple malignant eccrine poroma, basal cell carcinoma and cutaneous squamous cell carcinoma (CSCC) have all been reported to develop from a ver...