6'-(4-Chlorophenyl)-spiro[cyclohexane-1,2'-thieno[3,2-d][1,3] oxazin]-4'(1'H)-one (1) was synthesized and used as a starting material for the synthesis of a novel series of spiro compounds having biologically active sulfonamide 2a-e and 3'-(4-acetylphenyl)-6'- (4-chlorophenyl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d] pyrimidine-4'(3'H)-one (3). Compound 2a was used as a key intermediate for the...

we introduce the notion ofstrongly $alpha$-reversible rings which is a strong version of$alpha$-reversible rings, and investigate its properties. we firstgive an example to show that strongly reversible rings need not bestrongly $alpha$-reversible. we next argue about the strong$alpha$-reversibility of some kinds of extensions. a number ofproperties of this version are established. it is shown ...

A facile construction of the spiro[indole-3,2'-pyrrolidine] skeleton, through diacetoxyiodobenzene (PIDA) mediated C-N bond-forming dearomatization of C3 sulfonamide linked indole derivatives, has been developed. A variety of spiro-indolepyrrolidines were obtained in moderate to excellent yields under mild conditions.

An exploration of the chemistry of the spiro-mamakone system, exemplified by the cytotoxic, fungal metabolite spiro-mamakone A, is presented. The first reported synthesis of the spiro-mamakone carbon skeleton was achieved, as well as the synthesis of a variety of closely related analogues of the natural product. Biological testing of the synthetic analogues generated a structure-activity profil...

The crystal structures of the new compounds spiro[cyclohexane-1,3’-indol]-2’(1’H)-one (1), (rel-1R,2S)-spiro[bicyclo[2.2.1] heptane-2,3’-indol]-2’(1’H)-one (2) and spiro[indole-3,2’-tricyclo[3.3.1.1]decan]-2(1H)-one (3) have been determined by low temperature single crystal X-ray diffraction. The effects of substitution on the hydrogen bonding pattern is compared between all three compounds.

We have described an efficient gold-catalyzed double cyclization of 1,5-enynes to afford a range of heterobicyclic compounds, including oxabicylclo[3.2.1]octenes, azabicyclo[3.2.1]octenes, oxaspiro[5.4]decene, azaspiro[5.4]decene, oxaspiro[5.5]undecene, oxabicyclo[4.3.0]nonene, azabicyclo[4.3.0]nonene, and oxabicyclo[4.4.0]decene. The mechanism of this reaction is proposed to involve a chemosel...

in this paper, we introduce a class of rings which is a generalization of reversible rings. let r be a ring with identity. a ring r is called central reversible if for any a,b ∈ r, ab=0 implies ba belongs to the center of r. since every reversible ring is central reversible, we study sufficient conditions for central reversible rings to be reversible. we prove that some results of reversible ri...

The hole transport material (HTM) of organic–inorganic perovskite solar cells (PVSCs) plays a very important role for achieving high power conversion efficiency and long-term stability. 2,2’,7,7’-tetrakis[N,N-di(4-methoxyphenyl)amino]-9-9’-spirobifluorene (spiro-OMeTAD) is the first solid-state HTM used in PVSCs has gained tremendous attention during last decade. Herein, concept spirolinkage sy...

A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur ylides has been developed via a dearomatization strategy. Moreover, the spiro-cyclopropane compounds could be conveniently transformed to rearomatized indole derivatives in the presence of acids.