Background: We have recently shown that human embryonic (hESCs) and induced pluripotent stem cells (hiPSCs) can differentiate into advanced spermatogenic cells including round spermatids by in vitro culture (Easley et al., Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Reports 2, 440-446 2012) and also, in collaboration, that rhesus spermatogonial ...

Background: The qualitative computers (laptop) are as one of the sources of electromagnetic fields (EMF) and these waves are emitted from laptop when you are working with it or connecting to the internet (wireless).The aim of this study is assaying the effects of 2.4GHz waves on the spermatogenesis cycle at the time of connecting to the internet. Materials and Methods: In this study, 36 adult W...

The aim was to determine whether proton magnetic resonance spectroscopy (1H-MRS) of metabolites such as glycerophosphorylcholine (GPC), choline, citrate and lactate in human seminal plasma can be used to differentiate (i) different azoospermic patients and (ii) different forms of spermatogenic failure including those who had undergone radiation therapy or chemotherapy. Semen samples were provid...

As a persistent pollutant, microplastics (MPs) have been reported to induce sperm quantity decrease in mice. However, the related mechanism remains obscure. Therefore, this study is intended explore effects of polystyrene (PS-MPs) on male reproduction and its blood–testis barrier (BTB) impairment. Thirty-two adult Wistar rats were divided randomly into four groups fed with PS-MPs for 90 days at...

In Drosophila, the sex of germ cells is determined by cell-autonomous and inductive signals. XY germ cells autonomously enter spermatogenesis when developing in a female host. In contrast, XX germ cells non-autonomously become spermatogenic when developing in a male host. In first instar larvae with two X chromosomes, XX germ cells enter the female or the male pathway depending on the presence ...

Background: Protein-energy malnutrition is the most prevalent form of nutritional disorder in developing countries. Several studies have demonstrated that reproductive performance in adulthood is partially determined by a variety of extrinsic factors from conception to birth. Among these factors, maternal nutrition during fetal and neonatal life plays a key role as it can affect the reproductiv...

Spermatogenic immunoglobulin superfamily (SgIGSF) is a cell adhesion molecule originally discovered in mouse testis. SgIGSF is expressed not only in spermatogenic cells but also in lung and liver epithelial cells and in neurons and glia of the central and peripheral nervous systems. In the present study, we examined the expression and localization of SgIGSF in mouse olfactory epithelium before ...