The mutation spectrum of 175 β-thalassemia (β-thal) carriers, identified in pilot carrier screening on 22,713 individuals from Balearic Islands (Spain), is reported. The β(0) CD39 (C>T) mutation is the most frequent (61.1%), followed by β(+) IVS-I-110 (G>A) (12.0%), β(+) IVS-I-6 (T>C) and β(0) IVS-1-1 (G>A) (3.4% both) and eight other rare mutations (2.9-0.6%); with a distinct prevalence and di...

In this paper we present the asymptotic analysis of realised quadratic variation for multivariate symmetric β-stable Lévy processes, β∈(0,2), and certain pure jump semimartingales. The main focus is on derivation functional limit theorems its spectrum. We will show that limiting process a matrix-valued when original β-stable, while conditionally in case integrals with respect to locally motions...

The almost Mathieu operator is the discrete Schrödinger operator Hα,β,θ on `2(Z) defined via (Hα,β,θf)(k) = f(k+1)+f(k−1)+β cos(2παk+θ)f(k). We derive explicit estimates for the eigenvalues at the edge of the spectrum of the finite-dimensional almost Mathieu operator H α,β,θ. We furthermore show that the (properly rescaled) m-th Hermite function φm is an approximate eigenvector of H α,β,θ, and ...

In this paper, the structure of a new 16-membered macrocyclic Schiff base compound N,N′-(3,3′-dimethoxy-2,2′-(propane-1,3-diyldioxy)dibenzylidene)propane-1,3-diamine, C22H26N2O4 (1), derived from 1,3-propanediamine and 3,3′-dimethoxy-2,2′-(propane-1,3-diyldioxy)dibenzaldehyde has been studied by single crystal X-ray diffraction, DFT calculations at B3LYP/6-31G** and FT-IR spectroscopy. The titl...

Background & Aims: The production of extended-spectrum-β-lactamases (ESBLs) is the main mechanism of resistance to β-lactam antibiotics. The outbreak of isolates simultaneously possessing several resistance mechanisms to β-lactam antibiotics caused a decrease in sensitivity of the confirmatory tests for ESBL. The aim of this study was the evaluation of the β-lactamase disk test method in the de...

background guiana extended-spectrum (ges-2) as one of the extended-spectrum β-lactamases (esbls), produced by pseudomonas aeruginosa, is able to compromise the effectiveness of imipenem and tends to be geographically limited. objectives the aim of this study was to detect the spread of ges-2 β-lactamase gene among esbl- producing p. aeruginosa isolates in a teaching hospital in kashan, iran. ma...

The production of metallo-β-lactamases is the most important strategy by which pathogenic bacteria become resistant to currently known β-lactam antibiotics. The emergence of these enzymes is particularly concerning for the future treatment of bacterial infections. There are no clinically available drugs capable of inhibiting any of the metallo-β-lactamases, so there is an urgent need to find su...

The element β1 is the generator of the stable homotopy group π10(S ). Here S denotes the 3-localized sphere spectrum. Toda showed that β 1 6= 0 and β 1 = 0. Here we generalize it to β 1β9t+1 6= 0 and β 1β9t+1 = 0 for β9t+1 ∈ π144t+10(S) with t ≥ 0. In particular, β 1β10 6= 0 and β 1β10 = 0 for β10 shown to exist by Oka. This is proved by determining subgroups of π∗(L2S ), where L2 denotes the B...