The degradation behavior of cefixime trihydrate was investigated under different stress conditions of acidic hydrolysis, alkaline hydrolysis and oxidation using spectrophotometry. Stability indicating spectrophotometric methods were developed that could separate the drug from its degradation products formed under these stress conditions. The UV spectral characteristics of the drug and degraded ...

Literature survey reveals that few analytical methods were reported for the estimation of cinacalcet hydrochloride by LC, UV methods. Hence the present study aims in developing simple, rapid, precise and validated methods for cinacalcet hydrochloride in bulk. The methods are Colorimetric determination of Cinacalcet Hydrochloride by Visible Spectrophotometric method, Validation of Cinacalcet Hyd...

An enzyme-linked immunosorbent assay method was used to classify bovine serum as positive, negative, or doubtful for antibodies to Brucella abortus. Spectrophotometric data from assays of 64 serologically positive and 32 serologically negative bovine sera were analyzed statistically to define the range of spectrophotometric absorbance values which classify sera. Statistical analysis indicated t...

The thermal denaturation of the native DNA in solvents of varying salt concentrations was studied by viscometric and spectrophotometric methods. It was observed that within the molarity range of 0.02 M to 0.3 M, the melting temperatures obtained by the two independent methods agreed well, but that at lower ionic strength the agreement was not satisfactory. Both the visco­ metric and the spectro...

A small regional survey of direct spectrophotometric methods and a larger Australian and New Zealand survey of paediatric bilirubin analyses are described. The overall performance of both groups was unsatisfactory with an unacceptable high interlaboratory variation. This interlaboratory variation was reduced significantly by the use of a spectrophotometric method with a common standard of methy...

clarify if the spectrophotometric analysis of spent dialysate may allow the possibility to monitor the removal of β2M during HD. These results were obtained from the analyses of serum and spent dialysate samples of the 22 MHD patients (16 men, 6 women) of a previous study, where we confirmed the possibility to monitor the removal of small molecules, namely uric acid, by spectrophotometric analy...

First-ever three spectrophotometric methods using sulfanilamide (SAA), sulfadoxine (SDX) and sulfamethoxazole (SMX), the widely used sulfa drugs as new class of coupling agents for the spectrophotometric determination of cardol, a phenolic compound found in cashew nut shell liquid, a by-product of cashew industry is proposed. The methods are based on the interaction of diazotized sulfa drugs wi...

Micrococcus luteus was employed for the assay of rifampicin in fixed-dose combinations (FDCs) of anti-tubercular drugs containing rifampicin, isoniazid, pyrazinamide and ethambutal. The microbiological assay was compared with spectrophotometric assay for estimation of rifampicin in the FDCs as well as in dissolution studies of the FDCs. The microbiological method was found to be more sensitive ...