The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN). The antinuclear (ANA) and...

Low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (MAPK) signaling pathways. It has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (CGNs). In this study, we have examined the activation of JNK, p38kinase and ERK1/2 pathways in low glucose medium in CGNs. The CGNs were prepared ...

I N T R O D U C T I O N Pharmacological data were among the evidence which led to the view that the over-all electrophysiological manifestations of different excitable membranes are composites of a number of independently assorting electrogenic processes (Grundfest, 1961 a, b). Subsequently available data (cf. Grundfest, 1963, 1966 a, b) have reenforced this view, that the excitable membrane is a

A Primer on Mathematical Models in Biology Lee A. Segel and Leah Edelstein-Keshet This textbook grew out of a course that the popular and highly respected applied mathematician Lee Segel taught. It introduces differential equations, biological applications, and simulations and emphasizes molecular events, excitable systems, and small protein and genetic circuits. It is intended for upper-level ...

This paper proposes the Intra Trustcenter Protocol (ITP), a flexible and secure management protocol for communication between arbitrary trustcenter components. Unlike other existing protocols (like PKCS#7, CMP or XKMS) ITP focuses on the communication within a trustcenter. It is powerful enough for transferring complex messages which are machine and human readable and easy to understand. In add...

background: mesenchymal stem cells (mscs) are multipotent cells that can be collected from different sources. under specific conditions, mscs can be differentiated to tissue specific cells in vitro. human umbilical cord mesenchymal stem cells (hucmscs) can easily be harvested and cultured in in vitro conditions. production of germ cells from mesenchymal stem cells is a very interesting and prom...

Cellular and tissue activities highly depend on environmental pH. Murine lung tissue, when cultured properly in-vitro, is a potent producer of hematopoietic growth factors. We have studied the effect of pH on the production of hematopoietic growth factors and protein synthesis by the murine lung in-vitro. Various concentrations of NaHC03 were used to adjust the pH of the culture medium unde...

L-asparaginase is an anti-neoplastic agent used in the chemotherapy of lymphoblastic leukaemia. The present work deals with production of extra-cellular Lasparaginase from marine actinomycetes, using submerged fermentation. Marine actinomycete Streptomyces associated with marine spongeCallyspongia diffusa was isolated using specific ISP medium. Sponge-associated Streptomyces was character...