A section of this issue of TCRT focuses on four articles dealing with technological advances in brain and spine radiosurgery. With the evolution of radiation technology to allow for high precision image-guided radiotherapy as an integrated part of mainstream linear accelerators, the practice of stereotactic radiosurgery (SRS) is commonly applied to the brain and is rapidly developing as an attr...

Purpose: Ketogenic diets are high in fat and low in carbohydrates as well as protein which forces cells to rely on lipid oxidation and mitochondrial respiration rather than glycolysis for energy metabolism. Cancer cells (relative to normal cells) are believed to exist in a state of chronic oxidative stress mediated by mitochondrial metabolism. The current study tests the hypothesis that ketogen...

A retrospective study of 16 dogs with macroscopic soft tissue sarcomas was performed to evaluate response to a four-fraction radiotherapy protocol (prescribed dose of 32 Gy). Radiation was well tolerated with minimal side effects. The overall response rate was 50%, with seven partial responses and one complete response. The median time to progression was 155 days, and the median survival time w...

PURPOSE Ketogenic diets are high in fat and low in carbohydrates as well as protein which forces cells to rely on lipid oxidation and mitochondrial respiration rather than glycolysis for energy metabolism. Cancer cells (relative to normal cells) are believed to exist in a state of chronic oxidative stress mediated by mitochondrial metabolism. The current study tests the hypothesis that ketogeni...

Radiation induced skin fibrosis (RIF) is a debilitating sequela of radiation therapy, however the basic cellular pathophysiology driving this fibrotic development remains poorly defined. Clinically, fat grafting has been shown to improve fibrosis, but its mechanism unknown. We aimed delineate dynamics and associated pathways in RIF evaluate how these change with grafting-associated recovery irr...

PURPOSE To systematically review the evidence for the use of stereotactic radiosurgery or stereotactic fractionated radiation therapy in adult patients with malignant glioma. METHODS Key clinical questions to be addressed in this evidence-based review were identified. Outcomes considered were overall survival, quality of life or symptom control, brain tumor control or response and toxicity. M...