background sildenafil (viagra) has been introduced to treat erectile dysfunction by acting as phosphodiesterase 5 inhibitor and hence accumulation of guanosine cyclic monophosphate (cgmp). on the other hands, the nitric oxide/cgmp signaling pathway has crucial role in synaptic plasticity processes like long-term potentiation (ltp) in the central nervous system considered as a model of learning ...

background: our hearing ability in space is critical for hearing speech in noisy environment and localization. the spatial hearing questionnaire (shq) has been devised to focus only on spatial haring tasks (e.g., lateralization, distance detection and binaural detection). the aim of the present study was to determine the reliability and validity of the persian translation of the shq (spatial he...

in the present study, the effect of 5-ht2a receptor blockers in ca1 region of rat hippocampus on spatial learning was assessed in a t-maze, a spatial discrimination task. rats were canulated bilaterally and injected daily vehicle (saline), 5-ht2a-selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) and pirenperone (0.1, 0.3, 1.2 or 2.4 µg/0.5 µl) into the cannula 30 minutes before train...

introduction: patients with epilepsy can have impaired cognitive abilities. many factors contribute to this impairment, including the adverse effects of antiepileptic drugs like gabapentin (gbp). apart from anti-epilectic action, gabapentin is used to relieve ethanol withdrawal syndrome. because both gbp and ethanol act on gaba ergic system, the purpose of this study was to evaluate their effec...

background: sex steroids and their receptors exist in hippocampus and affect spatial learning and memory. this study was designed to measure testosterone level of ca1 and to assess the effect of spatial learning on its amount in left and right hippocampus of adult male rats. methods: sixteen rats were divided into two intact and castrated groups, and then trained in morris water maze (mwm). ano...

in this paper the minimum temperatures of 54 weather stations collected for a 31-year period were analyzed for zoning the frost regions in iran. the results of this study show that the average of the number of frost days per year was 62, and the average temperature was 3 degrees of centigrade below zero. dey the tenth month in the iranian calendar, december 22-january 20 with an average of 28, ...

the two-spotted spider mite, tetranychus urticae koch (acari: tetranychidae), is an economically important pest of ornamental plant in iran. the population abundance and spatial distribution were studied on five rosa cultivars including maroussia, wendela, elderado, wenedetta, and hot lady during two growing seasons of 2011 and 2012 in greenhouse. the k parameter, index of dispersion, lloyd’s m...