introduction: the magnocellular neurons (mcns) of the supraoptic nucleus (son) play a crucial role in control of physiological and pathophysiologiccal condition due to two peptides that they synthesize, i.e. oxytocin (oxt) and vasopressin (avp). the activity of mcns is regulated by a variety of excitatory and inhibitory inputs. opioid receptors are one of the important receptors in son synapses...

BACKGROUND AND AIM The aim of the report was to present a novel mutation in KCNH2 in a family with life-threatening long QT syndrome. METHODS A genetic study using the method of next generation sequencing was performed in a 47-year-old woman after several episodes of syncope and torsade de pointes after sudden stress, with familial history of sudden death in first-degree female relatives. The...

On the basis of patterns of anterograde, retrograde, and bi-directional transport of tracers from both the superior olivary nucleus (SON) and the torus semicircularis (TS), we report anatomical changes in brainstem connectivity across metamorphic development in the bullfrog, Rana catesbeiana. In early and late stages of larval development (Gosner stages 25-37), anterograde or bi-directional tra...

Sustainability of tundra vegetation under changing climate on the Yamal Peninsula, northwestern Siberia, home to the world’s largest area of reindeer husbandry, is of crucial importance to the local native community. An integrated investigation is needed for better understanding of the effects of soils, climate change and grazing on tundra vegetation in the Yamal region. In this study we applie...

Reiter's syndrome consists of a non-specific urethritis, conjunctivitis, polyarthritis, and a number of less constant features (Reiter, 1916). The cause of the urethritis is unknown but it is commonly regarded by venereologists as an infective condition of venereal origin. Although a yearly average of more than 12,000 cases of non-specific urethritis have been reported to the Ministry of Health...

The prohormone convertases (PCs) are processing enzymes that activate proproteins via cleavage at specific single or pairs of basic residues. The hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) are primary sites of biosynthesis of several neuroendocrine hormone precursors, including provasopressin (pro-AVP), pro-oxytocin (pro-OT), and procorticotrophin-releasing hormone ...

mRNA-splicing presents an important regulatory step that contributes to the functional repertoire of all cell types and tissues. Profound changes in alternative splicing have also been revealed during embryonic stem cell (ESC) differentiation. Based on a genome-wide screen for pluripotency regulators, Ng and colleagues now identify SON as a new splicing regulator in the maintenance of human ESC...

A simple analytical model of a nanoscale fully depleted dualmaterial gate (DMG) SOI and SON MOSFETs has been developed and their performance comparison analysis is presented in this paper. An analytical model for the surface potential and threshold voltage has been developed both for these structures using a generalized 2D Poisson’s equation solution. The DMG SON MOSFET technology is found to h...