Background: Modafinil is a CNS stimulant used to treat Narcolepsy, sleepiness and other disorders related sleep. It BCS class II drug having poor aqueous solubility.
 Objective: This study was aimed formulate evaluate orodispersible tablets of containing co-crystals for the improvisation critical attributes product such as dissolution rates, solubility oral bioavailability.
 Methods: ...

The section sensitivity profile (SSP) was well understood in the case of single-row-detector spiral CT. With the introduction of multi-row-detector spiral CT and the transition into cone-beam spiral CT, a revisit to the SSP issue becomes necessary. In this paper, the SSP of multi-row-detector spiral CT is formulated for the half-scan interpolation method at any transverse position. Based on the...

In most southern provinces of Iran, Soil Salinity is a growing problem particularly in the irrigated agricultural areas and has been found to reduce crop yields. In order to investigate the role of pod removal in seed germination, seedling growth and antioxidant enzymes activity in annual medics (Medicago scutella L.) under salinity stress conditions, a factorial experiment was conducted at Col...

An important factor in the development of sodium-ion batteries (SIBs) is use cheap and sustainable materials. Sodium lignosulfonate, a lignin derivative, demonstrated here as an attractive, “green”, water-soluble, potentially cost-effective binder for hard carbon anodes SIBs. A comparison its battery cycling performance made against other binders including sodium carboxymethyl cellulose lignin,...

Sodic soil is one of the most common problems of limiting agricultural production that related on irrigation. Saturated hydraulic conductivity is one of hydrodynamic characteristics in evaluating transmission flow through underground levels. To investigate the role of increment of exchangeable sodium in hydraulic conductivity changes (as characterized by the mobility of water in soil) an experi...

Terbinafine hydrochloride is a white to off-white fine crystalline powder. It is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water. Each tablet contains: Active Ingredients: terbinafine hydrochloride (equivalent to 250 mg base) Inactive Ingredients: colloidal silicon dioxide, NF; hydroxypropyl methylcellulose, USP; magnesium stearate, NF; micro...

An auxin-requiring soybean root callus metabolized [1-(14)C]-2,4-dichlorophenoxyacetic acid (2,4-D) to diethyl ether-soluble amino acid conjugates and water-soluble metabolites. The uptake in tissue varied with incubation time, concentration, and amount of tissue. Uptake was essentially complete (80%) after a 24-hour incubation and the percentage of free 2,4-D in the tissue fell to its lowest p...

Gastro retentive floating tablet of Simvastatin was prepared by direct compression technique using Methocel K4M as the rate controlling polymer. The hydrophilic cellulose derivative, Methocel K4M was evaluated for its gel forming and release controlling properties. Sodium bicarbonate and citric acid were incorporated as gas generating agents. The effects of soluble components (sodium bicarbonat...

The objective of this research was to improve the dissolution of simvastatin and to incorporate it in rapid disintegrating tablets (RDTs) with an optimized disintegration and dissolution characteristics. Polyoxyethylene-polypropylene block copolymer (poloxamer 188) was employed as a hydrophilic carrier to prepare simvastatin solid dispersions (SDs). Fourier transform infrared spectroscopy, diff...