To my dearest parents For their love, trust and supports ACKNOWLEGMENT I would like to thank my advisor, my thesis committee members, my research colleagues, my family and my friends who made this thesis possible. I would like to thank my thesis advisor, Mark Prausnitz for his support during my thesis work. Without his guidance, it would be difficult for me to complete my study. I would like to...

Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in treatment various diseases. However, owing dynamic nature immune system, this approach often been challenged by concerns regarding lack adequate long-term responses patients. The development microneedles (MNs) resulted improvement and expansion immuno-reprogramming strategies due housing high accumulatio...

In the current study hollow microneedles (HMNs) were fabricated by means of vat polymerization method for transdermal delivery insulin. Two geometries HMNs designed in a Computer Aided Design (CAD) software namely, curved pyramid and syringe-like with Liquid Crystal Display (LCD) method. Dimensions determined quality features imaged scanning electron microscopy (SEM). Volumetric characterizatio...

Skin wrinkles are an inevitable phenomenon that is brought about by aging due to the degradation of scleroprotein fibers and significant collagen reduction, which fundamental basis anti-wrinkle technology in use today. Conventional treatments such as lasering Botulinum toxin have some drawbacks including allergic skin reactions, cumbersome treatment procedures, inefficient penetration products ...