Research in recent years has demonstrated that biological molecules such as enzymes, immunoglobulins, and other proteins can be immobilized in sol-gel derived matrices and retain their biological function. Development ofglasses with encapsulated biomolecules has opened the possibility of solid-state optical biosensors for the detection and measurement of desired analytes. In this work, we repor...

In chemical analysis and electrochemical catalysis modified electrodes have been used in a wide range. In addition to the several methods of electrode modification reported in literature, the sol-gel route offers a possibility of preparing ceramic like films under rather mild conditions. This enhances the possibility of incorporation of temperature sensitive particles such as enzymes, microorga...

A study of PDMS (polydimethylsiloxane) sol-gel-coated channels fabricated using soft lithography and a laser direct writing technique is presented. PDMS is a biocompatible material that presents a high versatility to reproduce several structures. It is widely employed in the fabrication of preclinical devices due to its advantages but it presents a rapid chemical deterioration to organic solven...

This study describes a new means to conduct molecular recognition-based analysis using mass spectrometry. Taking advantage of the unique characteristic of the absorption capacity of the TiO(2) sol-gel material in the UV region, a TiO(2) sol-gel-deposited thin film was employed as the sample substrate to assist in UV laser desorption/ionization of analytes. Sol-gels are polymeric materials that ...

The cold gelation of preheated whey protein isolate (WPI) solutions at alkaline conditions (pH>10) has been studied to better understand the effect of NaOH in the formation and destruction of whey protein aggregates and gels. Oscillatory rheology has been used to follow the gelation process, resulting in novel and different gelation profiles with the gelation pH. At low alkaline pH, typical sol...

absorption spectra of the composite sol-gel (blue solid) and pure photochromic sol-gel (black solid). The open-form ∆OD for composite solgel (red dash). The inset is the chemical structure of the composite molecule with donor moiety (bottom red) and acceptor moiety (top blue). (d) The thermally reversing photokinetic measurement of the open-form ∆OD (460nm) of the composite sol-gel, recovering ...

Injectable Hydrogels In article number 2101284 by Chien-Chi Lin and co-workers, a biocompatible pH/thermo dual responsive injectable hydrogel is synthesized reversible addition-fragmentation chain-transfer (RAFT) polymerization acylhdrazone click chemistry. Upon injection, sol-gel transition occurs rapidly at body temperature the porous hydrogels degrade slowly under mild acidic condition due t...

A microfluidic chip that integrates a sol-gel derived affinity column with a microheater is developed. This microchip includes five electric heaters covered with patterned PMMA for individual heat elution from five sol-gels with target molecules. This study is the first to demonstrate the detection of proteinaptamer interactions on the sol-gel microfluidic system and further describes possible ...

Bronchorrhoea sputum separates into two phases--sol and gel--at low speed centrifugation (5000 g), although higher speed (160 000 g) is required to obtain complete separation. Markers of mucus glycoprotein and serum transudate have been estimated in sputum, sol, and gel in five cases of bronchorrhoea associated with chronic bronchitis, asthma, or alveolar cell carcinoma. In all samples markers ...

The entrapment of proteins using the sol-gel route provides a means to retain its native properties and artifi cially reproduce the molecular crowding and confi nement experienced by proteins in the cell allowing investigation of the physico-chemical and structural properties of biomolecules at the biotic/abiotic interface. The biomolecules are spatially separated and ‘caged’ in the gel structu...