Thyroid iodide uptake is basic to the clinical applications of radioiodine. Iodide uptake occurs across the membrane of the thyroid follicular cells through an active transporter process mediated by the sodium iodide symporter (NIS). The recent cloning of the NIS gene enabled the better characterization of the molecular mechanisms underlying iodide transport, thus opening the way to the clarifi...

Perchlorate has been detected in groundwater in many parts of the United States, and recent detection in vegetable and dairy food products indicates that contamination by perchlorate is more widespread than previously thought. Perchlorate is a competitive inhibitor of the sodium iodide symporter, the thyroid cell-surface protein responsible for transporting iodide from the plasma into the thyro...

background: exposure to arsenic is associated with impairment of male reproductive function by inducing oxidative stress. silymarin with an antioxidant property scavenges free radicals. objective: the aim of this study was to investigate if silymarin can prevent the adverse effects of sodium arsenite on ram sperm plasma membrane and acrosome integrity. materials and methods: ram epidydimal sper...

An 18-year-old 454-kg (1,000-lb) American Quarter Horse gelding was evaluated because of chronic intermittent malodorous right-sided nasal discharge. Endoscopy revealed a mycotic plaque in the nasal cavity adjacent to the nasomaxillary opening of the right caudal maxillary sinus. The nasomaxillary opening appeared to be larger than normal. Fungal culture of specimens of the mycotic plaque yield...

A protocol for the synthesis of α-alkynylnitrones from 1,3-enynes has been developed. The process is triggered by hydromagnesiation with magnesium hydride (MgH2), which prepared in situ through solvothermal treatment iodide (MgI2) sodium (NaH) tetrahydrofuran. Downstream functionalization resulting propargylmagnesium intermediates organo nitro compounds affords α-alkynylnitrones, could be used ...

The two families of systems formed by silver halides with alkali Chromates and tungstates have been systematically investigated in order to bring into evidence possible demixing phenomena. It has been found that silver chloride demixes with lithium Chromate and tungstate and with sodium tungstate; silver bromide demixes with lithium and sodium Chromates and tungstates; silver iodide demixes wit...

Numerous iodide-containing compounds are used in radiographic contrast media. Severe, untoward reactions to these agents are of two types, cardiorespiratory collapse and, less commonly, anaphylactic reactions (Goodman and Gilman, 1965). This paper reports a case of severe laryngeal oedema which developed as an allergic reaction to sodium metrizoate 75 per cent (Triosil) administered during card...

Differentiated thyroid cancers and their metastases frequently exhibit reduced iodide uptake, impacting on the efficacy of radioiodine ablation therapy. PTTG binding factor (PBF) is a proto-oncogene implicated in the pathogenesis of thyroid cancer. We recently reported that PBF inhibits iodide uptake, and have now elucidated a mechanism by which PBF directly modulates sodium iodide symporter (N...