Metabolic acidosis has recently been observed in rat models of salt-sensitive genetic hypertension. To test the hypothesis that salt sensitivity in humans may be associated with abnormal acid-base homeostasis, we performed arterial blood gas analyses in young (20-31 years old) normotensive subjects (n = 40) who were placed on a low salt diet (20 mmol NaCl/day) for 2 weeks with either 200 mmol s...

Isoji Sasagawa, MD, Department of Urology, Yamagata University, School of Medicine, 2-2-2 Iidanishi, Yamagata-shi, Yamagata 990-23 (Japan) pressure, bicarbonate and base excess. Sodium and potassium were determined by flame photometry. Chloride was measured by amperometric titration. BUN was determined by a diacetylmonoxime-thiosemicar-bizide reaction and creatinine was estimated with a modifie...

Because the use of phosphates has being recently diminished in meat industry due to the nutritional drawbacks of phosphates, some researchers started to evaluate sodium bicarbonate as phosphate replacer in meat products. The aim of this study was to evaluate the effect of different temperature combinations of dry air-cooking treatments (Air and Core temperatures: 160 76, 160 80, 200 76 and 200 ̊...

In situ perfusion of rat intestine was used to evaluate the effect of bicarbonate on the efficacy of a low sodium (35 mmol/l) glucose-electrolyte oral rehydration solution in normal and cholera toxin-treated rat small intestine. In normal intestine, absorption of water was greater (108 (8.1) microliters/min/g; p less than 0.01) and sodium secretion less (-4.3 (0.3) mumol/min/g; p less than 0.01...

BACKGROUND The effect of urinary alkalinization in cardiac surgery patients at risk of acute kidney injury (AKI) is controversial and trial findings conflicting. Accordingly, the authors performed a prospectively planned individual patient data meta-analysis of the double-blind randomized trials in this field. METHODS The authors studied 877 patients from three double-blind, randomized contro...

objective(s) motility plays a major role in pathogenicity of helicobacter pylori, yet there is  scarce data regarding its chemotactic behaviour. the present study was designed to investigate the chemotactic responses of local isolates of h. pylori towards various sugars, amino acids, as well as some other chemical substances. materials and methods chemotaxis was assayed by a modified adler’s me...

Acute hypoxia causes hyperventilation and respiratory alkalosis, often combined with increased diuresis and sodium, potassium, and bicarbonate excretion. With a low sodium intake, the excretion of the anion bicarbonate may be limited by the lower excretion rate of the cation sodium through activated sodium-retaining mechanisms. This study investigates whether the short-term renal compensation o...

CONTEXT Sodium bicarbonate has been suggested as a possible strategy for prevention of contrast medium-induced nephropathy, a common cause of renal failure associated with prolonged hospitalization, increased health care costs, and substantial morbidity and mortality. OBJECTIVE To determine if sodium bicarbonate is superior to sodium chloride for preventing contrast medium-induced nephropathy...

Sodium transport through various nephron segments is quite important in regulating sodium reabsorption and blood pressure. Among several regulators of this process, insulin acts on almost all the nephron segments and is a strong enhancer of sodium reabsorption. Sodium-proton exchanger type 3 (NHE3) is a main regulator of sodium reabsorption in the luminal side of proximal tubule. In the basolat...