The effects of corticosteroids on vascular tone have been recognized since the 1940s. However, despite repeated demonstration of pharmacological effects both in vitro and in vivo, their physiological significance as regulators of tone in health remains to be established. Evidence that abnormal vascular reactivity is important when adrenal steroid production is deranged is more convincing, and p...

Leiomyosarcoma is a malignant smooth muscle tumor. It the second most common primary retroperitoneal tumor behind liposarcoma. The léiomyosarcoma represents 11% of all tumors. age discovery between 40 and 60 years.

During the last decade, three main variations have been proposed for solving elliptic PDEs by means of collocation with radial basis functions (RBFs). In this study, we have implemented them for infinitely smooth RBFs, and then compared them across the full range of values for the shape parameter of the RBFs. This was made possible by a recently discovered numerical procedure that bypasses the ...

RGS2, a GTPase-activating protein (GAP) for G(q)alpha, regulates vascular relaxation and blood pressure. RGS2 can be phosphorylated by type Ialpha cGMP-dependent protein kinase (cGKIalpha), increasing its GAP activity. To understand how RGS2 and cGKIalpha regulate vascular smooth muscle signaling and function, we identified signaling pathways that are controlled by cGMP in an RGS2-dependent man...

one of the main goals of interpretation of gravity data is to detect location and edges of the anomalies. edge detection of gravity anomalies is carried out by different methods. terracing of the data is one of the approaches that help the interpreter to achieve appropriate results of edge detection. this goal becomes a complex task when the gravity anomalies have smooth borders due to gradual ...

We begin by considering second order dynamical systems of the from ẍ(t) + Γ(ẋ(t)) + λ(t)B(x(t)) = 0, where Γ : H → H is an elliptic bounded self-adjoint linear operator defined on a real Hilbert space H, B : H → H is a cocoercive operator and λ : [0,+∞)→ [0,+∞) is a relaxation function depending on time. We show the existence and uniqueness of strong global solutions in the framework of the Cau...

Unsupervised aggregation of independently built univariate predictors is explored as an alternative regularization approach for noisy, sparse datasets. Bipartite ranking algorithm Smooth Rank implementing this approach is introduced. The advantages of this algorithm are demonstrated on two types of problems. First, Smooth Rank is applied to two-class problems from bio-medical field, where ranki...

In the first part of these notes we survey results on entropy for smooth systems. We emphasize questions regarding existence and uniqueness of measures of maximal entropy, changes of topological entropy under perturbations, and entropy structures for smooth systems. In the second part of these notes we review topological pressure and equilibrium states for smooth systems. We look at existence a...

We introduce a self-consistent stochastic coarse-graining method, which includes both metric and scalar field fluctuations, to investigate the back reaction of long wavelength perturbations in single-scalar driven inflation, up to the second (one loop) order. We demonstrate that, although back reaction cannot be significant during the last 70 e-foldings of inflation with a smooth potential, the...

In this paper we shall show that certain estimates for the Euclidean wave equation also hold on Riemannian manifolds with smooth, strictly geodesically concave boundaries. By the last condition, we understand that the second fundamental form on the boundary of the manifold is strictly positive definite. We shall then give two applications of our estimates. First, we shall show that if n is the ...