Alias: LAM Note: Lymphangioleiomyomatosis (LAM) is a multisystem disease, affecting predominantly premenopausal women, that is characterized by proliferation of abnormal smooth muscle-like cells (LAM cells) leading to the formation of lung cysts, fluid-filled cystic tumors in the axial lymphatics (e.g., lymphangioleiomyomas), and abdominal tumors, primarily in the kidneys, comprising adipose ce...

BACKGROUND Neurofibromatosis type I (NF1) is a common autosomal dominant disorder with a broad array of clinical manifestations, including benign and malignant tumors, osseous dysplasias, and characteristic cutaneous findings. In addition, NF1 patients have an increased incidence of cardiovascular diseases, including obstructive vascular disorders. In animal models, endothelial expression of th...

Angioleiomyomas are benign smooth muscle tumors that originate from the tunica media of veins and arteries. They can occur anywhere in the body, but the preferential location of these tumors is the lower extremities. We describe a rare case of rectal angioleiomyoma and present our findings obtained by using computed tomography, magnetic resonance imaging, and histopathological analysis.

primary sarcomas of the kidney are exceptional. among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. the tumor usually arises from either the renal capsule or smooth muscle tissue in the renal pelvic wall. in this paper, we report a patient with leiomyosarcoma of the kidney presented with non-specific abdominal pain and a palpable mass. hi...

Extensive scientific literature data point to reciprocal interactions between prostate stromal cells and prostate cancer cells that likely regulate tumor progression. To investigate whether these intratumoral-reactive stromal cells in human prostate cancer are predictive of survival, tumor stroma volume and specific stroma markers were quantitated by using tissue microarrays (index tumors of 84...

the seed of croton tiglium l. (sct) is a well known folk medicine. in china, it has used to treat gastrointestinal disorders, intestinal inflammation, rheumatism, and so on. previous studies established its purgative and inflammation properties. in addition, the effects of essential oil of sct on intestinal transit and gastrointestinal tract has been studied. in the present study, we evaluated ...

conclusions these results showed an inhibitory effect for the extract of asafetida on muscarinic receptors of tracheal smooth muscle. results the ec50 obtained in the presence of higher concentration of the extract muscle was significantly higher compared to saline (p < 0.01). the maximum responses to methacholine in the presence of higher concentration of the extract (10 mg/ml) was significant...

•STUMPs are rare smooth muscle tumors with an overall favorable prognosis.•Pregnancy is possible after diagnosis of STUMP treated with myomectomy•Management of patients desiring fertility with STUMPs requires a multidisciplinary approach.

BACKGROUND Cutaneous smooth muscle tumors are rare and sometimes the differential diagnosis between leiomyoma and leiomyo-sarcoma is difficult and based in very subtle criteria. We therefore tried to investigate the use of p53 in such a conundrum. This marker has rarely been reported in cutaneous leiomyomas and even in more rare occasions, in cutaneous leiomyomas. MATERIAL AND METHODS We stud...

BACKGROUND Uterine leiomyoma is the most common benign tumor in reproductive-age women. Each leiomyoma is thought to be a benign monoclonal tumor arising from a single transformed myometrial smooth muscle cell; however, it is not known what leiomyoma cell type is responsible for tumor growth. Thus, we tested the hypothesis that a distinct stem/reservoir cell-enriched population, designated as t...