Magnetoencephalography (MEG) signals are influenced by skull defects. However, there is a lack of evidence of this influence during source reconstruction. Our objectives are to characterize errors in source reconstruction from MEG signals due to ignoring skull defects and to assess the ability of an exact finite element head model to eliminate such errors. A detailed finite element model of the...

In this paper we propose a method to include skull inhomogeneities in the EEG forward/inverse calculation by parcellating the skull based on a combination of skull anatomy and thickness. We show that it is enough to determine a few skull parameters (4 6) in the inverse search to capture the skull inhomogeneities if we also include the thickness. The validity of the linear relation between skull...

Recurrence of bacterial meningitis in children is not only potentially life-threatening, but also involves or induces psychological trauma to the patients through repeated hospitalization and multiple invasive investigations if the underlying cause remains undetected. Bacteria migration, along congenital or acquired pathways from the skull or spinal dural defects, gains entrance into the centra...

We used computer simulations to investigate finite element models [1] of the human skull in EEG source analysis. In the first part, we present a systematic investigation on the accuracy of different ways to account for the layered skull structure. We investigated local models, where each skull location was modeled differently, and global models, where the skull was assumed to be homogeneous, bo...

The low-conducting human skull is known to have an especially large influence on electroencephalography (EEG) source analysis. Because of difficulties segmenting the complex skull geometry out of magnetic resonance images, volume conductor models for EEG source analysis might contain inaccuracies and simplifications regarding the geometry of the skull. The computer simulation study presented he...

Dural sinus malformation is an extremely rare congenital cerebrovascular malformation. We report serial antenatal sonographic findings in two patients with dural sinus malformation. Sonography can reveal dural sinus malformation at 24 weeks' gestation. Correct and early diagnosis may help determine the appropriate place, timing, and mode of delivery, which may result in a better therapeutic cou...

non-penetrating head injuries associated with skull base fractures can lead to the development of pneumocephalus upon airs ingress, which leads its course in the subarachnoid space. intracerebral air accumulation is rare and ensuses when a paranasal sinus fracture is associated with a ensues when a paranasal sinus fracture is associated with a nearby parenchymal contusion. a 25-year old man is ...

valproic acid is one of the main antiepileptic drugs. there is an increased risk of neural tube defects and axial skeletal malformations among infants born to women who had received valproic acid. there is a hypothesis that one biochemical abnormality underlying the teratogenicity of valproic acid is a drug-induced reduction in maternal plasma zinc .in the present experimental study mated rats ...