Background: Allergen sensitization, symptom severity, pulmonary function test, and bronchodilator response are important in the diagnosis treatment of asthma. However, relationship between these factors remains unclear. Objective: The objective this study was to investigate aeroallergen sensitization asthma function, among pediatric patients with bronchial Methods: This a prospective where 155 ...

For years, methods have been available for the predictive identification of chemicals that possess the intrinsic potential to cause skin sensitization. However, many have proven less suitable for the determination of relative sensitizing potency. In this respect, the local lymph node assay (LLNA) has been shown to have a number of important advantages. Through interpolation of LLNA dose-respons...

Anne Marie Api Research Institute for Fragrance Materials, Inc. (RIFM), Woodcliff Lake, New Jersey, USA J.H.E. Arts TNO Quality of Life, Zeist, Netherlands Harmonization Project Document No. 5 4 David Basketter Unilever Safety and Environmental Assurance Centre, Sharnbrook, Bedford, United Kingdom Jonathan Chen Antimicrobials Division, Office of Pesticide Programs, Environmental Protection Agen...

Atopic dermatitis, hand eczema and contact sensitization are prevalent disorders, and may, in many cases, be secondary to skin barrier abnormality. The aim of this study was to investigate the association between self-reported generalized xerosis, atopic dermatitis, hand eczema and contact sensitization, taking filaggrin gene mutations into account. Questionnaire data were collected from a cros...

BACKGROUND Peanut allergy is increasing in prevalence due to unknown factors. A growing body of clinical evidence suggests sensitization to peanut occurs through the skin, supported by findings in mouse models. There is a need to identify environmental factors that promote epicutaneous sensitization to peanut. Triclosan is an antimicrobial found in household products that has been associated wi...

Unilever initiated a long-term research and capability development program in 2004 to evaluate and implement a new conceptual approach for assuring consumer safety without animal testing (Fentem et al., 2004, Westmoreland et al., 2010). Unilever’s approach for safety assessment is risk-based, meaning that all available data on a new ingredient (including predicted levels of consumer exposure du...

Epicutaneous sensitization has been an important route for protein allergen sensitization in atopic disease. Although the skin is irradiated by sunlight daily, the influence of visible light on epicutaneous sensitization has not been explored. In this study, by using a well-established murine protein-patch model, we show that low-energy visible light (LEVL) irradiation could differentially modu...

Risk factors for bronchial hyperresponsiveness have previously been established in the general community. In settings where occupational asthma is a risk, it has not been established whether occupational sensitization or measures of exposure are important. Bronchial responsiveness to histamine was measured in a cohort of 506 workers exposed to acid anhydrides. Skin-prick tests were performed wi...

Kress, M. and S. Guenther. Role of [Ca]i in the ATP-induced heat sensitization process of rat nociceptive neurons. J. Neurophysiol. 81: 2612–2619, 1999. In inflamed tissue, nociceptors show increased sensitivity to noxious heat, which may account for heat hyperalgesia. In unmyelinated nociceptive afferents in rat skin in vitro, a drop of heat threshold and an increase in heat responses were ind...

asthma, who attended for the first time to Allergy Department and collected data on clinical history, respiratory function and allergic sensitization. Asthma severity was classified using the GINA guide. We integreted the data into regression models to identify allergen sensitization most strongly associated with asthma severity. Results: We included 260 children with ages ranging from 3 to 18 ...