DRESS is a rare but life threatening drug allergic disease. The value of skin tests, especially patch-tests (PT) for defining the culprit drug were recently reported. Nevertheless DRESS has been associated with high risk of disease flare linked to drug rechallenge (culprit drug or not) or viral reactivation . In this study we analyzed the frequency of patch test-induced DRESS flares. Method Bet...

The epidermal growth factor receptor (EGFR) is often overexpressed or dysregulated in a variety of solid tumours, including gastrointestinal (GI) malignancies. Agents targeting the EGFR-mediated signalling pathway are increasingly part of the therapeutic armamentarium for the treatment of advanced lung, head-and-neck, and colorectal carcinoma. The EGFR inhibitors (EGFRIS) approved in Canada inc...

A ngioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma with a poor prognosis in which 50% of patients present with a rash. Although AITL’s cutaneous presentation is nonspecific, to our knowledge, a reticular rash is not described in published literature. Herein, we report a patient who presented with a generalized, netlike rash, confirmed to be AITL upon histologic analysis ...

orf is a mucocutaneous disease that occurs when non-intact skin comes into contact with contaminated sheep saliva. the lesions may complicate to lymphangitis or secondary bacterial infection, but systemic complications such as erythema multiforme, maculopapular rash, and generalized lymphadenopathy are rare. in this paper, we present two cases of erythema multiforme following orf disease.

Yaumatei Dermatology Clinic, 12/F Yaumatei Specialist Clinic (New Extension), 143 Battery Street, Yaumatei, Kowloon, Hong Kong A 21-year-old lady presented with right foot pain and numbness and a subsequent asthmatic attack with multiple purpuric rashes over the extremities. Blood tests showed peripheral blood eosinophilia. The constellation of clinical features and skin biopsy result were cons...

The epidermal growth factor receptor (EGFR) is often overexpressed or dysregulated in a variety of solid tumours, including gastrointestinal (GI) malignancies. Agents targeting the EGFR-mediated signalling pathway are increasingly part of the therapeutic armamentarium for the treatment of advanced lung, head-andneck, and colorectal carcinoma. The EGFR inhibitors (EGFRIs) approved in Canada incl...

Epidermal growth factor receptor (EGFR) inhibitors are widely used in the treatment of cancer. EGFR-targeted treatment is known to be associated with a high incidence of dermatological adverse reactions, including papulopustular rash, which can be dose-limiting and may affect compliance to treatment. Currently, the pathways involved in EGFR inhibitor-induced rash are poorly understood and few t...

Epidermal growth factor receptor overexpression in human cancer can be effectively targeted by drugs acting as specific inhibitors of the receptor, like erlotinib, gefitinib, cetuximab and panitumumab. A common adverse effect is a typical papulopustular acneiform rash, whose occurrence and severity are positively correlated with overall survival in several cancer types. We studied molecules inv...

During a meningococcal outbreak, 221 patients were studied. A skin rash was present in 78 (35.3%) patients. Twenty one (11.3%) patients had a frankly purpuric rash, involving mainly the extremities and the remaining had a generalised macular or petechial lesions. Extensive purpuric lesions, involving mainly the extremities were associated with disseminated intravascular coagulation (DIC), shock...