نتایج جستجو برای: skin permeation

تعداد نتایج: 200977  

2013
Teruko Imai Yuko Takase Harunobu Iwase Mitsuru Hashimoto

The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals. In the present study, we focused on the identification of rat dermal esterases and the hydrolysis of a prodrug during permeation across rat sk...

2013
M. Yousuf M. Ahmad M. Usman I. Ali

The present work was performed to develop and evaluate transdermal patches of combined antiasthmatic drugs (salbutamol sulphate and ketotifen fumarate). Polyvinyl alcohol membrane was used as backing membrane and eudragit RL-100 was used as matrix material to suspend the drugs in the continuous thickness of the patch. Methanol was solvent and propylene glycol was used as plasticizer. Tween 20, ...

2017
Paulina Carvajal-Vidal Mireia Mallandrich María Luisa García Ana Cristina Calpena

Halobetasol propionate (HB) is a potent synthetic corticosteroid used against inflammatory skin diseases, such as dermatitis, eczema, and psoriasis, among others. The aim of this study is to define how the presence of different skin penetration enhancers (nonane, menthone, limonene, azone, carene, decanol, linoleic acid and cetiol) affects the penetration and retention in skin of HB. To determi...

Journal: :Chemical & pharmaceutical bulletin 2002
Thorsteinn Thorsteinsson Már Másson Tomi Jarvinen Tapio Nevalainen Thorsteinn Loftsson

Various 4,5-dihydroisoxazol-3-yl fatty acid ester derivatives of cycloserine were synthesized to improve skin permeation of cycloserine. The ester derivatives were prepared by using the tert-butoxycarbonyl (t-Boc) protection strategy. The 4,5-dihydroisoxazol-3-yl esters were readily hydrolysed in an aqueous buffer solution, and the degradation profiles showed both specific acid and specific bas...

Journal: :Journal Biomedical and Biopharmaceutical Research 2017

Journal: :Biopharmaceutics & Drug Disposition 2019

2011
Myung Joo Kang Jae Yoon Eum Mi Sook Jeong Sang Han Park Ki Young Moon Mean Hyung Kang Min Soo Kim Sun Eun Choi Min Won Lee Do Ik Lee Hyoweon Bang Chung Soo Lee Seong Soo Joo Kapsok Li Mi-Kyung Lee Seong Jun Seo Young Wook Choi

BACKGROUND The aim of the present study was to enhance a topical delivery of hirsutenone (HST), a naturally occuring immunomodulator, employing Tat peptide-admixed elastic liposomes (EL/T). METHODS HST-loaded EL, consisting of phosphatidylcholine and Tween 80 (85:15 w/w%), were prepared using thin film hydration method. By adding Tat peptide to EL (0.16 w/w%), EL/T were formulated. The in vit...

2016
Alice Simon Maria Inês Amaro Anne Marie Healy Lucio Mendes Cabral Carlos Chagas Filho Valeria Pereira de Sousa

24 25 In the present study, in vitro permeation experiments in a Franz diffusion cell were performed 26 using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine 27 (RV) transdermal drug delivery system. In vitro-in vivo correlations (IVIVC) were examined 28 to determine the best model membrane. In vitro permeation studies across different synthetic 29 membranes ...

Journal: :European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2015
Ryotaro Miki Yasuna Ichitsuka Takumi Yamada Soichiro Kimura Yuya Egawa Toshinobu Seki Kazuhiko Juni Hideo Ueda Yasunori Morimoto

We aimed to develop a high-throughput screening (HTS) system for preliminary predictions of human skin permeability by using an artificial membrane that can mimic the permeation behaviour of lipophilic and hydrophilic compounds across the human skin. In this study, we synthesized a copolymer containing poly(dimethylsiloxane) (PDMS) and poly(ethylene glycol) (PEG) 6000 and impregnated it onto a ...

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