INTRODUCTION Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative, Gram-positive bacterium that can be isolated as a component of normal skin flora in humans. However, more recently, it has also been documented as a culprit in skin and soft tissue infections. We describe the clinical features of five individuals with S. lugdunensis-associated skin infections. We review the charac...

New antibiotics are needed because of the increased morbidity and mortality associated with multidrug-resistant bacteria. Iclaprim, a bacterial dihydrofolate reductase inhibitor, not currently approved, is being studied for the treatment of skin infections and nosocomial pneumonia caused by Gram-positve bacteria, including multidrug-resistant bacteria. Iclaprim showed noninferiority at -10% to ...

Job’s syndrome is characterized by the clinical features of fair skin, red hair, recurrent cold, staphylococcal skin abscesses with concurrent other bacterial infections and skin lesions. Hyperimmunoglobulin E syndrome (HIES) is a rare immune deficiency presenting with a trial of recurrent skin and pulmonary infections elevated IgE and eczematous reactions. The aim of this article is to review ...

The quinolone class of antimicrobial agents is one of most widely used classes of antimicrobial agents in outpatient and inpatient treatment. However, quinolone resistance in gram-positive and gram-negative bacteria has emerged and increased globally. This resistance limits the usefulness of quinolones in clinical practice. The review summarizes mechanisms of quinolone resistance and its epidem...

Eight hot topics regarding the diagnosis and management of bacterial skin infections were selected reviewed by five experts from different European countries, chosen based on their expertise in microbiology, infectious diseases, dermatology. As noninfectious diseases/conditions such as atopic dermatitis can be complicated infections, including Acute Bacterial Skin Structure Infections (ABSSSI),...

Background: Immunosuppressive drugs that are widely used to prevent acute and chronic organ rejections, predispose organ transplant patients to a variety of diseases including skin problems. This study aimed to determine the prevalence of skin lesions and to investigate their association with demographic characteristics in renal transplant patients. Methods: This cross-sectional study was perf...