Ulcerative colitis has a number of associated skin lesions. We report the case of a patient with active ulcerative disease presenting with rapidly progressive necrotic skin lesions, identified as thrombotic and requiring skin grafting. Thrombotic cutaneous gangrene is a rare but potentially serious manifestation of uncontrolled ulcerative colitis.

Aplasia cutis congenita (ACC) is a rare condition with an unclear pathogenic mechanism, although the condition has been suggested to occur as a result of the disrupted development or degeneration of skin in utero. ACC associated with fetus papyraceus has been described in numerous studies. Although there have been several reports of ACC, surgical treatment of ACC using the head as a site of don...

Hu Z, Zhu J, Cao X, Chan C, Li S, Guo D et al. Composite skin grafting with human acellular dermal matrix scaffold for treatment of diabetic foot ulcers: a randomized controlled trial. J Am Coll Surg 2016; 222: 1171–1179. The rates of wound healing were similar, as were rates of complications in this study that included 52 patients. Recurrent ulceration was less common in the group who had skin...

A 63-year-old man dropped a metal chunk onto his left foot during his work and suffered a crush injury of the left forefoot. He underwent Chopart's amputation followed by stump coverage with sole skin at the orthopedic department on the same day. He was referred to our department for reconstruction because of poor vascularization and subsequent necrosis of tissue at the stump. After the necroti...

The authors report the results achieved in patients with type III open tibial fractures who underwent primary autogenous bone grafting at the time of debridement and skeletal stabilisation. Twenty patients with a mean age of 35.8 years (range, 24-55) were treated between 1996 and 1999. Eight fractures were type IIIA, 11 were type IIIB, and 1 was type IIIC. At the index procedure, wound debridem...

Crandall CG, Davis SL. Cutaneous vascular and sudomotor responses in human skin grafts. J Appl Physiol 109: 1524–1530, 2010. First published June 17, 2010; doi:10.1152/japplphysiol.00466.2010.—Each year millions of individuals sustain burns. Within the US 40,000–70,000 individuals are hospitalized for burn-related injuries, some of which are quite severe, requiring skin grafting. The grafting p...

Ehlers-Danlos syndrome is a heritable connective tissue disorder with an estimated prevalence of one in 10,000 to 25,000 persons [1]. Using clinical phenotype, biochemical and molecular defects, as well as inheritance patterns, a total of 6 subtypes have been described [2]. Although its hallmark findings include severe joint laxity and hyperextensible skin, this condition is known to affect a v...

This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author’s clinical r...

Destruction of the skin and subcutaneous tissues of the lower limb is often associated with injury to underyling tendons or bone. Sometimes the skin lesions are allowed to heal by granulation, or they are closed more rapidly by the application of split-skin grafts, and the results of such treatment may be entirely satisfactory. But healing by granulation often leads to chronic ulceration, and h...

In addition to providing a physical barrier, skin also serves a diverse range of physiological functions through different specialized resident cell types/structures, including melanocytes (pigmentation and protection against ultraviolet radiation), Langerhans cells (adaptive immunity), fibroblasts (maintaining extracellular matrix, paracrine regulation of keratinocytes), sweat glands (thermore...