BACKGROUND The anterolateral thigh (ALT) perforator flap has become a popular option for treating soft tissue defects of lower extremity reconstruction and can be combined with a segment of the vastus lateralis muscle. We present a comparison of the use of the ALT fasciocutaneous (ALT-FC) and myocutaneous flaps. METHODS We retrospectively reviewed patients in whom free-tissue transfer was per...

HYPOTHESIS Dissection of subnipple tissue to spare the entire skin envelope of the breast (total skin-sparing mastectomy) is a feasible option in appropriately selected patients and yields an excellent final cosmetic outcome. DESIGN Prospective surgical technique outcomes study. SETTING University-based breast care referral center. PATIENTS Total skin-sparing mastectomy with preservation ...

OBJECTIVE Phosphodiesterase-5 inhibitors, used to increase penile blood flow in erectile dysfunction patients, have recently been postulated to increase blood flow and flap survival in cutaneous flaps based on random blood supply. This study aims to investigate the phosphodiesterase-5 inhibitor tadalafil, administered orally, on random flap survival. METHODS Modified McFarlane flaps measuring...

Abstract Skin ischemia-reperfusion (I/R) injury is a serious condition that compromises skin flap surgery and leads to organ dysfunction. It arose due restoration of blood supply after prolonged ischemia. The present study was conducted explore the possible protective Isoliquiritigenin (ISL) on in rats. ISL administered rats dose 10 mg/kg, 20 30 mg/kg. effect quantified tissue following I/R var...

OBJECTIVE To investigate the clinical application of a pedicled forearm flap in the reconstruction of soft tissue defects after oral cancer resection. METHODS A retrospective analysis was performed on 31 patients with oral cancer in the Affiliated Stomatology Hospital of Kunming Medical University. The patients underwent repair of soft tissue defects, resulting from oral cancer resection, usi...

BACKGROUND Alprostadil and sildenafil are known vasodilators used independently to improve flap survival in animal models. In this study, we investigate whether these agents act synergistically to decrease flap necrosis in rat models. METHODS After acclimation period, 4 groups of 10 male white rats were given a modified McFarlane skin flap. The postoperative treatment included saline control ...

conclusions scarring of the neck produces problems with function, and appearance. in our view, the supraclavicular flap, a thin flap of good texture, is an excellent and highly reliable flap for covering defects of the anterior neck. this flap is easy to harvest, with good functional and aesthetic results. results thirty-seven of the 41 flaps survived completely, but there were three cases of d...

68 WOUNDS www.woundsresearch.com Abstract: Objective. The purpose of this study was to reveal the effect of N-acetylcysteine (NAC) on random-skin flaps in rats. Introduction. N-acetylcysteine is an agent among free radical scavengers which is used primarily as a mucolitic agent. Experimental studies have demonstrated protective effects of NAC on hepatic, renal, lung, and intestinal injuries. Me...

BACKGROUND The free fibular osteocutaneous flap is a commonly used flap for mandible and buccal mucosa reconstruction in head and neck cancer surgery. However, the skin paddle restriction from the intermuscular septum often limits the soft tissue reconstruction. METHODS We have proposed a new modified chimeric fibular osteocutaneous flap design based on the combination of a traditional fibula...

OBJECTIVE To develop a computational model of cutaneous wound closures comparing variations of the rhombic transposition flap. STUDY DESIGN A nonlinear hyperelastic finite element model of human skin was developed and used to assess flap biomechanics in simulated rhombic flap wound closures as flap geometric parameters were varied. SETTING In silico. METHODS The simulation incorporated va...