Abstract During skin injury, immune response and repair mechanisms have to be coordinated for rapid regeneration the prevention of microbial infections. Natural Killer (NK) cells infiltrate hypoxic lesions Hypoxia-inducible transcription factors (HIFs) mediate adaptation low oxygen. We demonstrate that mice lacking factor (HIF)-1α isoform in NK show impaired release cytokines Interferon (IFN)-γ...

Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) ...

BACKGROUND Surgical site infections are the third most frequent type of nosocomial infections. Evidence-based recommendations have been given regarding preoperative hospitalization, hygiene and air-conditioning, patient conditions, and wound dressing. However, no general recommendations concerning wound closure exist. Systematic reviews and meta-analyses suppose a benefit of intracutaneous sutu...

Tropoelastin (TE), the soluble precursor of insoluble elastin fibers, is produced in minimal amounts in adults. Burn injuries result in inflexible collagen-rich scars because of lack of elastin fiber formation. We studied the feasibility of using recombinant human tropoelastin to enable elastin fiber production in burn and surgical scars to improve skin flexibility. In a swine hypertrophic burn...

Closure of large skin wounds (i.e., burns, congenital giant nevus, reconstruction of traumatic injury) with split-thickness skin grafts requires extensive harvesting of autologous skin. Composite grafts consisting of collagen-glycosaminoglycan (GAG) substrates populated with cultured dermal fibroblasts and epidermal keratinocytes were tested in a pilot study on full-thickness burn wounds of thr...

BACKGROUND suturing techniques employed to close subcuticular surgical incisions are varied. PURPOSE we present the "bow-tie" stitch, which is removed by pulling one side of the stitch with no need for sharp object stitch cutting. The stitch results in good approximation and scarring while enabling proper oozing. METHODS we have used this suture repeatedly for wound closure after hip and kn...

While minimally invasive parathyroidectomy is an advantage to many properly selected patients, longer incisions and even wide skin resection may be optimal in a select few. We present an 80-year-old woman with primary hyperparathyroidism and bothersome excess neck skin and subcutaneous fat. The parathyroid adenoma was easily excised through a vertically-oriented cervical excision that removed a...

Abstract Aim A surgical patient post fasciotomy presents a challenge to restore cover of the muscle groups. The use suturing dermatotraction techniques cheap and easy means native cover. This systematic review case series controls explored trend this technique including duration delayed primary wound closure, complications failure rates. Method literature was conducted on Medline, Embase CINAHL...

Fournier’s gangrene is a rapidly progressive, fatal, necrotizing fasciitis of the perineum and penoscrotal region which requires rapid intervention. This retrospective study compares surgical outcomes fasciocutaneous flap embedding testicles into thigh skin, applied for reconstruction defects after debridement due to gangrene, in light literature. A total 110 patients treated at Çanakkale Onsek...