This study was designed to evaluate the effects of strontium on the expression levels of microRNAs (miRNAs) and to explore their effects on skeletal cell proliferation, differentiation, adhesion, and apoptosis. The targets of these miRNAs were also studied. Molecular cloning, cell proliferation assay, cell apoptosis assay, quantitative real-time PCR, and luciferase reporter assay were used. Str...

osteopoikilosis is a rare benign osteosclerotic bone disorder that may be misdiagnosed as skeletal metastases. here we describe a case of coincidental breast cancer and osteopoikilosis mimicking skeletal metastases. a 41-year-old woman underwent right modified radical mastectomy in april 2007. twenty-eight months after initial treatment, the patient complained of bilateral knee and foot pain. p...

satellite cells (scs) are the most abundant skeletal muscle stem cells. they are widely recognized for their contributions to maintenance of muscle mass, regeneration and hypertrophy during the human life span. these cells are good candidates for cell therapy due to their self-renewal capabilities and presence in an undifferentiated form. presently, a significant gap exists between our knowledg...

The nature, biological characteristics, and contribution to organ physiology of skeletal stem cells are not completely determined. Chan et al. and Worthley et al. demonstrate that a stem cell for skeletal tissues, and a system of more restricted, downstream progenitors, can be identified in mice and demonstrate its role in skeletal tissue maintenance and regeneration.