This paper aims to provide an optimization framework for coded caching that accounts for various heterogeneous aspects of practical systems. An optimization theoretic perspective on the seminal work on the fundamental limits of caching by Maddah Ali and Niesen is first developed, whereas it is proved that the coded caching scheme presented in that work is the optimal scheme among a large, non-t...

In two-stage surveys, the sample size of clusters and units within clusters can be chosen to minimise the variance of an estimator, for fixed cost. This paper considers sample designs where the number of units to be selected from each cluster is a function of the cluster size. If there are only a small number of units in each cluster, as in household surveys, then the optimisation should be ove...

This report focuses on the PSF properties and plate scale optimization for the Near-IR channel of WFC3. We discuss how various effects lead to the final observed PSF in NICMOS Camera 2 and suggest apodization of the cold stop as a possible way to improve contrast for the Near-IR channel of WFC3. We derive a model for the pixel response of the NICMOS arrays and use this model to produce simulate...

This paper examines the optimal production lot size decisions for clinical trial supply chains. One unique aspect of clinical trial supply chains is the risk of failure, meaning that the investigational drug is proven unsafe or ineffective during human testing and the trial is halted. Upon failure, any unused inventory is essentially wasted and needs to be destroyed. To avoid waste, manufacture...

Purpose: To prepare and optimize esomeprazole nanosuspension to enhance drug dissolution rate. Methods: Esomeprazole nanosuspensions were prepared by evaporative precipitation-ultrasonication method using F68 (Poloxamer 188) and F127 (Poloxamer 407) as stabilizers. Formulation and process variables (concentration of stabilizers and drug, power input and duration of ultrasonication) affecting th...

The incremental solution building capability of ant algorithm is exploited in this paper for the efficient layout and pipe size optimization of sanitary sewer network. Layout and pipe size optimization of sewer networks requires that the pipe locations, pipe diameters and pipe slopes are optimally determined. This problem is a highly constrained mixed-integer nonlinear programming (MINLP) probl...

This paper covers application of an elitist selfadaptive step-size search (ESASS) to optimum design of steel frame structures. In the ESASS two approaches are considered for improving the convergence accuracy as well as the computational efficiency of the original technique namely the so called self-adaptive step-size search (SASS). Firstly, an additional randomness is incorporated into the sam...

the goal of this research is preparation, optimization and in-vitro evaluation of rifampin-loaded silica nanaoparticles in order to use in pulmonary drug delivery. nanoparticles are exhaled because of thier small size, preparation of nanoaggregates in micron-sized scale and re-disrpersion of them after the deposition in the lung is one approach in order to overcome this problem, which we used i...

In this study, a new meta-heuristic algorithm called teaching-learning-based optimization (TLBO) is used for the size and shape optimization of structures. The TLBO algorithm is based on the effect of the influence of a teacher on the output of learners in a class. The cross-sectional areas of the bar element and the nodal coordinates of the structural system are the design variables for size a...