*Corresponding author: Dr. Jaimala sharma, Department of Zoology, University of Rajasthan, Jaipur-302055, India. E-mail: [email protected] Background: Radiotherapy is the main modality of cancer treatment. There are many chemical radioprotectors which unfortunately have lethal or toxic effect. Therefore the search is on to find out natural plant based radioprotectors. A well known medi...

Mutational activation of the K-ras oncogene often occurs in human and mouse lung adenocarcinomas. Since K-ras p21 functions in trans-membrane signaling, we have investigated whether the amount of this protein in lung cell membranes is a variable that could influence lung tumorigenesis, either due to genetic differences or in response to tumor promoters. The six mouse strains assessed showed lit...

Defects in the human ferrochelatase gene lead to the hereditary disorder of erythropoietic protoporphyria. The clinical expression of this autosomal dominant disorder requires an allelic combination of a disabled mutant allele and a low-expressed nonmutant allele. Unlike most other erythropoietic protoporphyria populations, mutations identified among Swiss erythropoietic protoporphyria families...

We describe some of the aspects of Swiss-Prot that make it unique, explain what are the developments we believe to be necessary for the database to continue to play its role as a focal point of protein knowledge, and provide advice pertinent to the development of high-quality knowledge resources on one aspect or the other of the life sciences.

SWISS-PROT is an annotated protein sequence database established in 1986 and maintained collaboratively, since 1988, by the Department of Medical Biochemistry of the University of Geneva and the EMBL Data Library BAIROCH, Amos Marc, BOECKMANN, Brigitte. The SWISS-PROT protein sequence data bank. Nucleic Acids Research, 1991, vol. 19 Suppl, p. 2247-9 DOI : 10.1093/nar/19.suppl.2247

The accuracy of multiple sequence alignment program MAFFT has been improved. The new version (5.3) of MAFFT offers new iterative refinement options, H-INS-i, F-INS-i and G-INS-i, in which pairwise alignment information are incorporated into objective function. These new options of MAFFT showed higher accuracy than currently available methods including TCoffee version 2 and CLUSTAL W in benchmar...