Salvia columbariae extracts were examined for the presence of salvianolic acids by HPLC-MS and NMR. A new salvianolic acid, β-sitosterol lithospermic acid, was found.

BACKGROUND AND PURPOSE The object of our study was to compare the effect of high-dose vs low-dose atorvastatin vs nonstatin-based treatment (cholestyramine plus sitosterol) on cell composition of carotid plaque. METHODS We recruited 60 hypercholesterolemic patients (total cholesterol, 5.83-7.64 mmol/L) eligible for carotid endarterectomy. Three months before surgery, patients were randomized ...

OBJECTIVES The purpose of the study was to investigate whether cholesterol metabolism is associated with coronary artery disease (CAD) in postmenopausal women. BACKGROUND Although hypercholesterolemia, a predominant risk factor of CAD, is related to cholesterol metabolism, the association between cholesterol metabolism and CAD is not well known. METHODS In addition to conventional coronary ...

Amaç: Bu çalışmada, farelerde beta-sitosterol uygulamasına bağlı santral analjezide opioiderjik, serotonerjik, adrenerjik ve kolinerjik reseptörleri ile ilişkili olası antinosiseptif aktivitesi araştırılmıştır. Gereç Yöntem: Beta-sitosterol, farelere 5, 10 20 mg/kg dozlarında uygulandı. Daha sonra, fareler beta-sitosterolün etkilerini araştırmak için tail-flick hot-plate testleri analiz edildi....

BACKGROUND Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upon the genetics of sitosterolemia, ABCG5/sterolin-1 and ABCG8/sterolin-2 are h...

The effects of feeding cholesterol, sitosterol, and lovastatin on cholesterol absorption, biosynthesis, esterification, and LDL receptor function were examined in the rat jejunal mucosa. Cholesterol absorption was measured by the dual-isotope plasma ratio method; the rate-limiting enzyme of cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, was measured as tota...