Human c-sis/PDGF-B proto-oncogene has been shown to be overexpressed in a large percentage of human tumor cells establishing a growth-promoting, autocrine growth circuit. Triplex forming oligonucleotides (TFOs) can recognize and bind sequences in duplex DNA, and have received considerable attention because of their potential for targeting specific genomic sites. The c-sis/PDGF-B promoter contai...

INTRODUCTION Impulsivity is a complex phenomenon that can be evaluated from a trait or state perspective. Impulsive trait is a predisposition relatively stable over time, but not always perceptible by behavior. However, the impulsivity state covers transient variations on impulsivity levels that are dependent on environmental or biologic conditions. OBJECTIVE This study has aimed to validate ...

Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic transition from yeast to hyphae during a-α opposite-sex mating and α-α unisexual reproduction (same-sex mating). Infectious spores are generated during both processes. We previously identified a sex-induced silencing (SIS) pathway in the C. neoformans serotype A var. grubii lineage, in which tandem transgene arrays tr...

We evaluated the efficiency of the best linear unbiased predictor (BLUP) and the influence of the use of similarity in state (SIS) and similarity by descent (SBD) in the prediction of untested maize hybrids. Nine inbred lines of maize were crossed using a randomized complete diallel method. These materials were genotyped with 48 microsatellite markers (SSR) associated with the QTL regions for g...

An important question regarding autocrine transformation by v-sis is whether intracellularly activated PDGF receptors are sufficient to transform cells or whether activated receptor-ligand complexes are required at the cell surface. We have addressed this question by inhibiting cell surface transport of a membrane-anchored v-sis protein utilizing the ER retention signal of the adenoviral transm...

Strategic information systems (SIS) focus on the use of information system (IS) and information technology (IT) in the strategic management process in business organizations. The emphasis is on the strategic view of IS and IT and their impact on organizational strategy. Increased competition and advances in information technologies push for considerable structural changes in SIS. Agents, as aut...

OBJECTIVE Subacromial impingement syndrome (SIS) is a frequent cause of shoulder pain. The aim of this study was to investigate the diagnostic values of clinical diagnostic tests, in patients with SIS. METHODS 72 female, 48 male patients with shoulder pain were included in the study. Five had bilateral shoulder pain, so 125 painful shoulders were evaluated. Details were recorded about the pat...

We investigated the reliability of the Structured Interview for Schizotypy-Revised (SIS-R). The original interview (SIS) was developed by Kendler. We revised the SIS, primarily by standardizing the rating procedures. Operational definitions and explicit criteria for rating were given. We introduced a four-point scale and provided clear criteria for rating severity of symptoms and signs (frequen...

This paper first describes the characteristics of the Slow Intelligence System (SIS), and then provides an example of Petri Net modeling of the topic/trend detection system by applying the SIS principles. The Petri Net model is simulated using PIPE3 tool. Based upon the requirements for Slow Intelligence Systems, a survey of existing development framework leads to suggestions for a generic fram...

The secure identification of a person was and still of great interest in different fields of human activities. The traditional identification methods such as PIN, passwords aren’t capable to achieve a high level of secure identification. In the contrast, the biometrics allows to attain the suitable solution for this vital question. Different types of biometrics are reviewed. Its characteristics...