1. Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil. 2. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil. Mailing address: Dra. Aline de Araújo Naves. Universidade Federal do Triângulo Mineiro. Avenida Getúlio Guaritá, 130, Nossa Senhora da Abadia. Uberaba, MG, Brazil, 38025-440. E-mail: r...

Human Papilloma Virus (HPV) can play a causative role in the development of sinonasal tract malignancies. In fact, HPV may be the most significant causative agent implicated in sinonasal tumorigenesis and is implicated in as many as 21% of sinonasal carcinomas. To date, there are no definitive, reliable and cost-effective, diagnostic tests approved by the FDA for the unequivocal determination o...

OBJECTIVE To evaluate the oncologic outcomes of patients with sinonasal cancer treated with endoscopic resection. DESIGN Retrospective review. SETTING Tertiary care academic cancer center. PATIENTS All patients with biopsy-proved malignant neoplasm of the sinonasal region who were treated with endoscopic resection between 1992 and 2007 were included in the study, and their charts were rev...

Undifferentiated pancreatic carcinoma with osteoclast-like giant cells (UPC-OGCs) is a rare neoplasm with frequency of 0.2 % of reported pancreatic carcinomas [1]. Tumors with osteoclast-like giant cells have rarely been reported in a variety of extra-skeletal sites. On the alimentary tract, the pancreas is the most concerned [2, 3]. A number of terms have been used to describe variants of undi...

Introduction: Sinonasal malignancies are uncommon neoplasms with several histological subtypes. These malignancies have a poor prognosis and, because of the nonspecific nature of the symptoms, most patients are diagnosed late when the disease is already at an advanced stage. Therefore, most sinonasal malignancies tend to be treated with surgery and postoperative radiotherapy. Understanding the ...

Undifferentiated carcinoma (also known as anaplastic carcinoma) of the thyroid gland is a highly aggressive malignant neoplasm composed of undifferentiated cells that exhibit immunohistochemical or ultrastructural epithelial differentiation. Nearly all patients report a long history of thyroid gland disease, often goiter or Hashimoto thyroiditis. In most cases, there is a transformation from a ...

Epididymal tumors are uncommon and usually benign, with only 25% of them being malignant. Undifferentiated epididymal carcinoma in particular is extremely rare. We report on a 54-year-old male patient presented with right testicular pain and scrotal mass for the last 6 months. Laboratory investigations were unremarkable but epididymal biopsy result was epididymal undifferentiated carcinoma. Ing...