Bu çalışmada, bitki ekstrelerinde oksidatif stres biyobelirteçleri için yöntem performansının kabul edilebilirliğini değerlendirmek biyolojik varyasyonlar ve analitik kalite spesifikasyonlarının saptanması amaçlandı. Araştırmada Silybum marianum (Deve Dikeni) Artemisia absinthium (Pelin Otu) kullanıldı. Bitkilerden 0.,1., 3., 5., 7., 15. 30. günlerde örnekler alındı. Bitki [katalaz (CAT) supero...

Bu çalışmada deve dikeni tohumu ununun bug day unu ile farklı oranlarda hazırlanan karışımlarının tavuk köftelere % 7.5 oranında ilavesinin kızartma sonrası köftelerin bazı özellikleri üzerine etkisi araştırılmıştır. Hazırlanan köfteler 180 °C'de 7 d kızartıldıktan sonra verim, çap azalması, renk değerleri, nem tutma, yağ emme oranı ve duyusal yönden değerlendirilmiştir. Sonuç olarak, buğday un...

Silybin is a secondary metabolite isolated from the seeds of blessed milk thistle (Silybum marianum) that has anti-inflammatory, antioxidative, antifibrotic, and antitumor properties. Here, we showed that silybin protected against cisplatin-induced acute kidney injury (AKI) by improving mitochondrial function through the regulation of sirtuin 3 (SIRT3) expression. Male SV129 and SIRT3 knockout ...

Silybin (a flavonolignan, the main component of silymarin, an extract from the seeds of Silybum marianum) has been used to date mostly as a hepatoprotectant. However, it also has other interesting activities, e.g., anticancer and hypocholesterolemic effects. It is also known that silybin can inhibit the activities of the cytochrome P450 (P450) enzymes. In this study, a weak interaction of silyb...

Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Silibinin, a polyphenolic flavonoid derived from fruits and seeds of Silybum marianum, has been reported to possess various potent beneficial biological effects, such as antioxidant, anti-cancer, hepatoprotective and anti-inflammatory activities. However, the anti-inflammatory effects of...

Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of glucose and lipid metabolism. Agonists of this nuclear receptor are used in the treatment of type 2 diabetes and are also studied as a potential treatment of other metabolic diseases, including nonalcoholic fatty liver disease. Silymarin, a concentrated phenolic mixture from milk thistle (Silybum marianum) seeds, is ...

DEAR EDITOR, We read with respect the paper “Protective role of Silymarin and deferoxamine against iron dextran induced renal iron deposition in male rats by Nematbakhsh et al. It is an interesting paper; however, I would like to add some complementary comments to it. In this paper the Silymarin reduced the kidney iron deposition in an iron overload model. The findings have demonstrated that Si...