Explosion chambers are crucial to the technology used prevent coal mine gas explosions. Investigating shock wave propagation law at various tunnel cross-sections helps ensure safety. A self-built, highly explosive experimental setup was conduct empirical research on straight tubes, eight sizes of single-stage explosion chambers, and multi-stage tandem chambers. Ansys Fluent numerical simulation...

objective: rna interference (rnai) is the most potent technique for gene silencing in eukaryotic cellular system at transcriptomic level. genetic disorders and cancers are important targets for therapeutic development of this technique. in order to bypass the temporary dpwnregulation by sirna, a new generation of shrna named shrnamir has developed. silencing construct with structure similar to ...

RE-1 silencer of transcription/neural restrictive silencer factor (REST/NRSF), a transcriptional repressor, binds to the RE-1 element present in many vertebrate genes. In vitro studies indicate that REST/NRSF plays important roles in several stages of neural development. However, a full understanding of its physiological function requires in vivo approaches. We find that impairment of REST/NRSF...

Regulation of the Escherichia coli bgl promoter involves the catabolite gene activator protein (CAP) and silencer elements that are located upstream and downstream of the promoter and its CAP binding site. The promoter is kept in a repressed state by the silencer elements and other normally active CAP-dependent or -independent promoters are repressed as well when flanked by these elements. To a...

A previous theoretical study [L. Huang, J. Acoust. Soc. Am. 119, 2628-2638 (2006)] shows that, in a duct, a simply supported plate covering a side-branch rigid cavity can function effectively as a wave reflector over a broad range of low to medium frequencies. In this study, analytical formulation is extended to the boundary condition of clamped plate, which is easier to implement in practice. ...

In Saccharomyces cerevisiae, genes located at the telomeres and the HM loci are subject to transcriptional silencing. Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing when targeted to a silencer-defective HMR locus.