Bone cells in culture responded to parathyroid hormone (PTH) and prostaglandin E2 (PGE2) by a 2-fold increase in creatine kinase (CK) activity. Combined treatment resulted in a higher response than with PTH alone. Calcitonin (CT) failed to stimulate CK activity, did not affect the response of CK to PTH, but inhibited slightly the increase in CK activity by PGE2. Bone-cell cultures grown in low ...

We studied the role of phosphorus retention in parathyroid cell proliferation and parathyroid hormone (PTH) oversecretion in severe secondary parathyroid hyperplasia. Mice transplanted with human parathyroid tissue from a patient who had undergone parathyroidectomy for severe secondary hyperparathyroidism were divided into four groups; each group was given a diet with a different phosphorus con...

INTRODUCTION Postoperative parathyroid hormone (PTH) levels as a predictor of hypocalcaemia in patients subjected to total thyroidectomy is analyzed. MATERIAL AND METHOD Prospective study involving 67 patients who underwent total thyroidectomy due to a benign disease. Serum PTH and ionised calcium were measured 20 h after surgery. Sensitivity, specificity and predictive values of PTH and ioni...

Phosphate retention plays an important role in the pathogenesis of secondary hyperparathyroidism in patients with renal failure. In in vitro studies, high extracellular phosphate levels directly stimulate PTH secretion in rat and bovine parathyroid tissue. The present study evaluates the effect of high phosphate levels on the secretion of PTH and the production of prepro PTH mRNA in human hyper...

OBJECTIVE To systematically assess the literature regarding the clinical, histological, and radiographic outcome of bone morphogenetic proteins (BMP-2, BMP-7), growth/differentiation factor-5 (GDF-5), platelet-derived growth factor (PDGF), and parathyroid hormone (PTH) for localized alveolar ridge augmentation. MATERIAL AND METHODS Five separate Medline searches were performed in duplicate fo...

Serum1, 25-dihydroxyvitamin D •k1, 25(OH)2D•l, parathyroid hormone (PTH), calcitonin (CT), calcium, inorganic phosphorus and alkaline phosphatase (Al-P'ase) levels were determined in24patients with senile or postmenopausal osteoporosis, which was diagnosed by lateral X-ray film of lumbar vertebrae and divided into3 stages, porosis score I, II and III according to its severity. Serum calcium in ...

Histomorphometry studies in rhesus monkeys have shown that daily treatment with full-length parathyroid hormone 184 (PTH) increases bone formation and bone volume. However, there is no published information on the effects of PTH treatment on bone microarchitecture in humans. We obtained iliac crest biopsies from postmenopausal osteoporotic women given daily injections of placebo or 100 Ìg PTH f...

Objectives. In this study we aimed to investigate causes of hyperparathyroidism and related factors in postmenopausal women. Methods. The study was conducted on 156 postmenopausal women, 43 with normal serum parathyroid hormone (PTH) levels and 113 with elevated serum PTH levels. Serum levels of 25-OH vitamin D, calcium and phosphorus, 24-hour urine calcium, phosphorus and calcium/creatinine ra...