Here, we describe the isolation and characterization of the rhesus macaque homolog for human DC-SIGN, a dendritic cell-specific C-type lectin. mac-DC-SIGN is 92% identical to hu-DC-SIGN. mac-DC-SIGN preserves the virus transmission function of hu-DC-SIGN, capturing and efficiently transducing simian and human immunodeficiency virus to target CD4(+) T cells. Surprisingly, however, mac-DC-SIGN pl...

The present study tracked activation pattern differences in response to sign language processing by late hearing second language learners of American Sign Language. Learners were scanned before the start of their language courses. They were scanned again after their first semester of instruction and their second, for a total of 10 months of instruction. The study aimed to characterize modality-...

Dendritic cell (DC)-based vaccines have shown promise as an immunotherapeutic modality for cancer and infectious diseases in many preclinical studies and clinical trials. Provenge (sipuleucel-T), a DC-based vaccine based on ex vivo-generated autologous DCs loaded with antigens, has recently received FDA approval for prostate cancer treatment, further validating the potential of DC-based vaccine...

Dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) expressed on a variety of DCs, is a C-type lectin receptor that recognizes glycans on a diverse range of pathogens, including parasites. The interaction of DC-SIGN with pathogens triggers specific signaling events that modulate DC-maturation and activity and regulate T-cell activation by DCs. In this work we evaluate whether F. hepa...

The ubiquitous presence of cell-surface sialic acid (SIA) has complicated efforts to identify specific transmembrane glycoproteins that function as bone fide entry receptors for influenza A virus (IAV) infection. The C-type lectin receptors (CLRs) DC-SIGN (CD209) and L-SIGN (CD209L) enhance IAV infection however it is not known if they act as attachment factors, passing virions to other unknown...

Human herpesvirus 8 (HHV-8) causes Kaposi's sarcoma and pleural effusion lymphoma. In this study, we show that dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209) is a receptor for HHV-8 infection of myeloid DCs and macrophages. DC-SIGN was required for virus attachment to these cells and DC-SIGN-expressing cell lines. HHV-8 binding and infection were blocked by anti-DC-SIGN mA...

In this paper we propose a method termed as Face-Specific Subspace DCT Sign Only Product (FSS–DSOP), for face recognition. The proposed method is based on Face-Specific Subspace (FSS) technique using Discrete Cosine Transform (DCT) sign only product as similarity measure. The proposed approach aims to improve the recognition rate of the FSS technique under small size scenario with illumination ...

I replicate Donohue and Levitt’s results for violent and property crime arrest rates and then apply their data and specification to an analysis of age-specific homicide rates and murder arrest rates. The coefficients on the abortion rate have the wrong sign for two of the four measures of crime and none is statistically significant at conventional levels. In the second half of the paper, I pres...

This paper describes the creation of annotation standards for glossing sign language corpora as part of the Digging into Signs project (2014-2015, http://www.ru.nl/sign-lang/projects/digging-signs/). This project was based on the annotation of two major sign language corpora, the BSL Corpus (British Sign Language) and the Corpus NGT (Sign Language of the Netherlands). The focus of the gloss ann...

OBJECTIVES The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. METHODS We administered executive, semantic, verb-production, and syntactic...