BACKGROUND AND PURPOSE The purpose of this study was to examine the reliability and validity of data obtained with 2 newly developed shuttle run tests (SRT-I and SRT-II) to measure aerobic power in children with cerebral palsy (CP) who were classified at level I or II on the Gross Motor Function Classification System (GMFCS). The SRT-I was developed for children at GMFCS level I, and the SRT-II...

Carbonic anhydrases (CAs) catalyze the reversible hydration of CO(2) to HCO(3)(-) and H(+). The rate-limiting step in this reaction is the shuttle of protons between the catalytic center of the enzyme and the bulk solution. In carbonic anhydrase II (CAII), the fastest and most wide-spread isoform, this H(+) shuttle is facilitated by the side chain of His64, whereas CA isoforms such as carbonic ...

We consider the optimal scheduling of a nite capacity shuttle in a two node network with imperfect information. When shuttle trips do not depend on the number of passengers carried, we prove optimality and monotonicity of threshold policies. We derive conditions for dispatching which reduce the computational eeort required to compute an optimal threshold policy. We provide a counterexample to t...