Two reasons for the lack of success of programs or interventions are poor alignment of interventions with the causes of the problem targeted by the intervention, leading to poor efficacy (theory failure), and failure to implement interventions as designed (program failure). These failures are important for both public health programs and randomized trials. In the Sanitation Hygiene and Infant N...

Regulatory elements in genetic data are often short and variable, their identification and discovery using computational algorithms is difficult. A model based on communication theory concepts and used by Dawy, et al., [1], is used to model the process of translation in gene expression. The model assumes the ribosome decodes the mRNA sequence by using the 3’ end of the 16SrRNA molecule as an em...

Stanford Health Information Network for Education (SHINE) integrates online guideline texts, textbooks, journals, bibliographic systems, medical images, digital video, relational databases, and knowledge-based systems, which were formerly accessible individually through the Z39.50 protocol, SQL language, HTTP protocol, and full-text search engines. We introduce the architecture that is used to ...

The L11 ribosomal protein operon of Escherichia coli contains the genes for L11 and L1 and is feedback regulated by the translational repressor L1. The mRNA target site for this repression is located close to the Shine-Dalgarno sequence for the first cistron, rp1K (L11). By use of a random mutagenesis procedure we have isolated and characterized a series of point mutations in the L11 leader mRN...

This contribution summarizes the current status and future plans of the NA61/SHINE experiment located at CERN SPS. This experiment is the successor of a former NA49 experiment. The broad physics program includes the investigation of the properties of strongly interacting matter, as well as precision measurements of hadron production for the T2K neutrino experiment and for the Pierre Auger Obser...