Shift work or transmeridian travel can desynchronize the body's circadian rhythms from local light-dark cycles. The mammalian suprachiasmatic nucleus (SCN) generates and entrains daily rhythms in physiology and behavior. Paradoxically, we found that vasoactive intestinal polypeptide (VIP), a neuropeptide implicated in synchrony among SCN cells, can also desynchronize them. The degree and durati...

BACKGROUND This study investigates the prevalence of symptoms of shift work disorder in a sample of nurses, and its association to individual, health and work variables. METHODOLOGY/PRINCIPAL FINDINGS We investigated three different shift work disorder assessment procedures all based on current diagnostic criteria and employing symptom based questions. Crude and adjusted logistic regression a...

OBJECTIVE Night-shift work is associated with ischaemic cardiovascular disorders. It is not currently known whether it may be causally linked to metabolic syndrome (MS), a risk condition for ischaemic cardiovascular disorders. The syndrome presents with visceral obesity associated with mild alterations in glucidic and lipidic homeostasis, and in blood pressure. The aim of this study was to asse...

Millions of people worldwide are working at times that overlap with the normal time for sleep. Sleep problems related to the work schedule may mediate the well-established relationship between shift work and increased risk for disease, occupational errors and accidents. Yet, our understanding of causality and the underlying mechanisms that explain this relationship is limited. We aimed to asses...

An important practical problem in real world schedule execution is the occurrence of unforeseen events. When any changes in a production environment occur, the schedule has to be revised. Considering time consuming and shop floor nervousness, reactive repair of a disrupted schedule is a better alternative to total rescheduling. Most of the researchers have focused on heuristic based schedule re...

BACKGROUND Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors. METHODS We conducted a prospective, randomized study comparing the rates of serious medical errors made by interns while they were working according to a traditional schedule with extended (24 hours or more) work shifts every other shift (an "eve...

background and objectives: work sampling is a useful technique to characterize how employees allocate their work time to various activities. given the value of nurses’ time for quality health care delivery, characterization of nursing time distribution may provide useful information for optimal use of nursing staff. the purpose of the present study was to explore time allocation by nurses using...

The Modal-Shift Transportation Planning Problem (MSTPP) is the problem that finds a feasible schedule for carriers with the minimum total cost when sets of facilities, delivery orders, and carriers are given. In this paper, we propose a fast steepest descent algorithm to solve the MSTPP. Our solution generates a set of candidate routes for each delivery order as a preprocess. Then, it finds a s...

Time Schedule is a detailed division of work duration on each project work. The problem in this study the ineffectiveness and amount done not accordance with planned duration. purpose was to evaluate time schedule using network planning method determine critical trajectory by Microsoft Project 2016 software accelerate from its original acceleration adding labor, increasing working hours acceler...

The effects of night shift schedules on circadian time structure of blood pressure were studied in seven healthy young subjects by continuous monitoring of blood pressure every 30 min for 72 h. In the control experiment, subjects were instructed to sleep at regular times with the light off at 00.00 h and the light on at 07.00 h. In the shift experiment, they were instructed to go to bed at 06.0...