The transient receptor potential vallinoid type 4 (TRPV4) channel has been implicated in the endothelial shear response and flow-mediated dilation, although the precise functions of this channel remain poorly understood. In the present study, we investigated the role of TRPV4 in shear stress-induced endothelial Ca(2+) entry and the potential link between this signaling response and relaxation o...

Shear stress is an important parameter in estimating the slope stability and flow dynamics mass movements. The ring shear test can often be employed to determine residual because of its suitability for large deformations assumed situ drainage conditions. Determination weathered landslide materials composed coarse-grained sediments was examined with respect displacement condition. Based on exper...

We study the dynamics of the Taylor-Couette flow of shear banding wormlike micelles. We focus on the high shear rate branch of the flow curve and show that for sufficiently high Weissenberg numbers, this branch becomes unstable. This instability is strongly subcritical and is associated with a shear stress jump. We find that this increase of the flow resistance is related to the nucleation of t...

Sickle erythrocytes exhibit abnormal morphology and membrane mechanics under deoxygenated conditions due to the polymerization of hemoglobin S. We employed dissipative particle dynamics to extend a validated multiscale model of red blood cells (RBCs) to represent different sickle cell morphologies based on a simulated annealing procedure and experimental observations. We quantified cell distort...

We studied the extreme hemodilution to a hematocrit of 11% induced by three plasma expanders: polyethylene glycol (PEG)-conjugated albumin (PEG-Alb), 6% 70-kDa dextran, and 6% 500-kDa dextran. The experimental component of our study relied on microelectrodes and cardiac output to measure both the rheological properties of plasma-expander blood mixtures and nitric oxide (NO) bioavailability in v...

abstract to resist lateral loads in concrete buildings, usually systems such as flexural frame, shear wall or their combinations are used. using x form of cable bracing in order to strengthen concrete buildings is a new method. this system is more economical compared with the other systems due to cables low weight, high tensile resistance, easy performance and less maintenance problems. in this...

Solids are distinguished from fluids by their ability to resist shear. In equilibrium systems, the resistance to shear is associated with the emergence of broken translational symmetry as exhibited by a nonuniform density pattern that is persistent, which in turn results from minimizing the free energy. In this work, we focus on a class of systems where this paradigm is challenged. We show that...

Weak bonding between layers of pavement leads to damages on the composite pavement. Bonding plays an important role in the durability and maintenance of composite pavement layers. The present study evaluates the factors effective in bond strength of the interface between concrete and asphalt pavements. The factors considered for this purpose include steel slag percentage in the concrete pavemen...

The system of steel shear wall is an initiative resistance system against the lateral load such as an earthquake and the wind that has been researched in the last three decades. Currently, this system is noticed more than other systems because of adequate stiffness, ductility, and more energy absorption. The system of steel shear wall with corrugated sheets has been offered as an innovative sys...