BACKGROUND Succinic acid is well established as bio-based platform chemical with production quantities expecting to increase exponentially within the next decade. Actinobacillus succinogenes is by far the most studied wild organism for producing succinic acid and is known for high yield and titre during production on various sugars in batch culture. At low shear conditions continuous fermentati...

Fluid shear stress enhances NO formation via a Ca-independent tyrosine kinase inhibitor–sensitive pathway. In the present study, we investigated the effects of the protein tyrosine phosphatase inhibitor phenylarsine oxide and of fluid shear stress on endothelial NO production as well as on the membrane association and phosphorylation of the NO synthase (NOS) III. Phenylarsine oxide (10 mmol/L) ...

The present study tested whether primary cilia on macula densa serve as a flow sensor to enhance nitric oxide synthase 1 (NOS1) activity and inhibit tubuloglomerular feedback (TGF). Isolated perfused macula densa was loaded with calcein red and 4,5-diaminofluorescein diacetate to monitor cell volume and nitric oxide (NO) generation. An increase in tubular flow rate from 0 to 40 nl/min enhanced ...

This study examines the formation of Hurricane Gabrielle (2001), focusing on whether an initial disturbance and vertical wind shear were favorable for development. This examination is performed by running numerical experiments using the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5). Gabrielle is chosen as an interesting case to stu...

Introduction: The biggest challenge that orthodontist face in the clinical practice is debonding of the brackets. The best way to avoid bond failure is to adhere strictly to the rules of good bonding. Aims and Objectives: Aims and objectives of the study were to measure shear bond strength of orthodontic brackets which were rebonded using different tooth surface reconditioning methods that are ...

Food industry cleaning operations must efficiently mitigate any risk of remaining unwanted contamination without consuming large amounts water, chemicals and energy. This study's originality was in analysing the capacity flowing foams to remove Bacillus spores from stainless steel surfaces. A set-up designed allow formation wet flow under three differing regimes: bubble-size rearrangement obser...

Nitric oxide (NO) produced by the endothelium is involved in the regulation of vascular tone. Decreased NO production or availability has been linked to endothelial dysfunction in hypercholesterolemia and hypertension. Shear stress-induced NO release is a well-established phenomenon, yet the cellular mechanisms of this response are not completely understood. Experimental limitations have hinder...

Hemodynamic conditions vary throughout the vasculature, creating diverse environments in which platelets must respond. To stop bleeding, a growing platelet deposit must be assembled in the presence of fluid wall shear stress (τw) and a transthrombus pressure gradient (ΔP) that drives bleeding. We designed a microfluidic device capable of pulsing a fluorescent solute through a developing thrombu...

Fluid shear stress enhances NO formation via a Ca2+-independent tyrosine kinase inhibitor-sensitive pathway. In the present study, we investigated the effects of the protein tyrosine phosphatase inhibitor phenylarsine oxide and of fluid shear stress on endothelial NO production as well as on the membrane association and phosphorylation of the NO synthase (NOS) III. Phenylarsine oxide (10 microm...

In this research in-plane shear Behavior of composite steel-concrete shear walls was investigated considering the Effects of steel plates thickness, spaces between shear studs, shape and type of shear studs and existing of minimum reinforcement in wall section. Several finite element models were analyzed and Numerical results of two models were taken under verification with existent experimenta...