Hemodynamic shear stresses cause endothelial cells (ECs) to polarize in the plane of the flow. Paradoxically, under strong shear flows, ECs disassemble their primary cilia, common sensors of shear, and thus must use an alternative mechanism of sensing the strength and direction of flow. In our experiments in microfluidic perfusion chambers, confluent ECs developed planar cell polarity at a rate...

An investigation has been made to analyze the effects of viscous dissipation on the heat transfer characteristics for both hydro-dynamically and thermally fully developed, laminar shear driven flow between two infinitely long parallel plates, where the upper plate is moving in an axial direction at a constant speed. On the basis of some routine assumptions made in the literature, a close form a...

Unsteady hydromagnetic generalised Couette flow of a viscous, incompressible and electrically conducting fluid between two horizontal parallel porous plates Darcian channel in the presence of a uniform transverse magnetic field taking Hall current and ion-slip into account in a rotating system is investigated. An exact solution of the governing equations is obtained by Laplace transform techniq...

The behavior of a single polyethylene chain grafted to an impenetrable surface, under shear flow, is investigated using Brownian dynamics simulations. Both short-range conformational energies and excluded volume effects are included in the model. Simulations are performed in good and poor solvent conditions in order to explore the effect of solvent quality. The shear flow is represented by the ...

Rotation and shear flows are ubiquitous features of many astrophysical and geophysical bodies. To understand the origin of large-scale shear flow and its effect on turbulent transport in these systems, we consider a forced turbulence and investigate the combined effect of rotation and shear flow on the turbulence properties. Specifically, we study how rotation and flow shear influence the gener...

The conformational dynamics of a single protein molecule in a shear flow is investigated using Brownian dynamics simulations. A structure-based coarse grained model of a protein is used. We consider two proteins, ubiquitin and integrin, and find that at moderate shear rates they unfold through a sequence of metastable states-a pattern which is distinct from a smooth unraveling found in homopoly...

OBJECTIVE Blood flow is considered one of the important parameters that contribute to venous thrombosis. We quantitatively test the relationship between initiation of coagulation and shear rate and suggest a biophysical mechanism to understand this relationship. METHODS AND RESULTS Flowing human blood and plasma were exposed to cylindrical surfaces patterned with patches of tissue factor (TF)...

We study the dynamics of the Taylor-Couette flow of shear banding wormlike micelles. We focus on the high shear rate branch of the flow curve and show that for sufficiently high Weissenberg numbers, this branch becomes unstable. This instability is strongly subcritical and is associated with a shear stress jump. We find that this increase of the flow resistance is related to the nucleation of t...

Time-dependent shear stress versus shear rate, constitutive curve, and velocity profile measurements are reported in entangled polymer solutions during start-up of steady shear flow. By combining confocal microscopy and particle image velocimetry (PIV), we determine the time-dependent velocity profile in polybutadiene and polystyrene solutions seeded with fluorescent 150 nm silica and 7.5 μm me...