In the adult central nervous system, neural stem cells (NSCs) reside in two discrete niches: subependymal zone (SEZ) of lateral ventricle and subgranular (SGZ) dentate gyrus (DG). Here, NSCs represent a population highly specialized astrocytes that are able to proliferate give rise neuronal glial progeny. This process, termed neurogenesis, is extrinsically regulated by other niche such as non-s...

It has become generally accepted that new neurones are added and integrated mainly in two areas of the mammalian CNS, the subventricular zone and the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus, which is of central importance in learning and memory. The newly generated cells display neuronal morphology, are able to generate action potentials and receive functional synapt...

Substantial evidence has demonstrated that dendritic protein synthesis is an important source of new protein during the expression of synaptic plasticity. Dendritically synthesized brain-derived neurotrophic factor (BDNF) has been shown to be key in the expression of lasting synaptic plasticity. However little is known about the function of dendritic protein synthesis in other cellular forms of...

Background & Aims: Neurogenesis in the adult mammal brain occurs throughout life. Adult neurogenesis has been clearly demonstrated in the sub granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. Pheromones that plays an essential role in the development of the central nervous system. The male pheromones are involved in regulating neurogenesis in both the olfactory bulb and hippocam...

Abstract INTRODUCTION Radiotherapy is the primary local intervention for cerebral metastases (BMs). Despite decades of advancements in this field, inadvertent collateral irradiation adjacent healthy tissue proximity to neoplastic site remains a persistent challenge. Neural stem cells (NSCs), crucial establishment and preservation nervous system, exhibit heightened sensitivity radiation. Consequ...

Oligodendrocyte precursor cells (OPCs) are a unique type of glial cells that function as oligodendrocyte progenitors while constantly proliferating in the normal condition from rodents to humans. However, the functional roles they play in the adult brain are largely unknown. In this study, we focus on the manner of OPC proliferation in the hippocampus of the young adult mice. Here we report tha...

It is now recognized that neurogenesis occurs throughout life predominantly in the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricle. In the present study, we investigated the relationship between neurogenesis in the amygdala and extinction of fear memory. Mice received 15 tone-footshock pairings. Twenty-four hours after training, the mice were...