The adrenal gland is composed of two ontogenetically and functionally distinct t issues, the medulla and the cortex. The cortex, the subject of the present art icle, forms the major part of the murine gland and is further organized into three concentric layers: the outer zona glomerulosa, the zona fasciculata and the innermost X-zone. Specific hormonal production is finely tuned in t ime and sp...

INTRODUCTION Gelatinous Heberden's nodes (HNs), also termed synovial cysts, are a common form of generalized osteoarthritis (OA). We sought to determine whether HN cases at clinical presentation contained multipotential stromal cells (MSCs) and to explore whether such cells were more closely related to bone marrow (BM) or synovial fluid (SF) MSCs by transcriptional analysis. METHODS At clinic...

23 24 25 Recent studies of myocardial infarction in secreted Frizzled-related protein 2 (sFRP2) 26 knockout mice and our hamster heart failure therapy based on sFRP2 blockade have 27 established sFRP2 as a key profibrotic cytokine in the heart. The failing hamster heart is marked 28 by prominent fibrosis and calcification with elevated expression of sFRP2. Noting the 29 involvement of tissue-no...

Martin S, Lin H, Ejimadu C, Lee T. Tissue-nonspecific alkaline phosphatase as a target of sFRP2 in cardiac fibroblasts. Am J Physiol Cell Physiol 309: C139–C147, 2015. First published May 13, 2015; doi:10.1152/ajpcell.00009.2015.—Recent studies of myocardial infarction in secreted Frizzled-related protein 2 (sFRP2) knockout mice and our hamster heart failure therapy based on sFRP2 blockade have...

Rickets and osteomalacia are associated with hypophosphatemia in several disease states, including X-linked hypophosphatemic rickets, autosomal-dominant hypophosphatemic rickets, and tumor-induced osteomalacia. Recent advances in the understanding of these diseases include discovery of mutations in the genes encoding human phosphate-regulating gene with homologies to endopeptidases on the X chr...

Starker, L. 2013. New Insights in Genetic and Epigenetic Mechanisms Involved in Parathyroid Tumorigenesis. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 927. 36 pp. Uppsala. ISBN 978-91-554-8727-0. Primary hyperparathyroidism (pHPT) is a pathology associated with one or multiple hyperfunctioning parathyroid glands. The dise...

BACKGROUND In the endometrium the steroid hormone progesterone (P), acting through its nuclear receptors, regulates the expression of specific target genes and gene networks required for endometrial maturation. Proper endometrial maturation is considered a requirement for embryo implantation. Endometrial receptivity is a complex process that is spatially and temporally restricted and the identi...

BACKGROUND Limited information is available regarding mechanisms by which miRNAs contribute to pulmonary carcinogenesis. The present study was undertaken to examine expression and function of miRNAs induced by cigarette smoke condensate (CSC) in normal human respiratory epithelia and lung cancer cells. METHODOLOGY Micro-array and quantitative RT-PCR (qRT-PCR) techniques were used to assess mi...

alteration in methylation pattern of promoters is associated with tumorigenic events,(1, 2) and differentiation control,(3, 4) in several types of cells in humans.specific hypermethylation in promoter region of some genes exist in different types of neoplastic cells.(5) dna methylation indicates to the addition of a methyl moiety to the cytosine in a cpg dinucleotide. cpg dinucleotides tend to ...