Small fibre neuropathy (SFN) is characterised by structural injury selectively affecting small diameter sensory and/or autonomic axons. The clinical presentation is dominated by pain. SFN complicates a number of common diseases such as diabetes mellitus and is likely to be increasingly encountered. The diagnosis of SFN is demanding as clinical features can be vague and nerve conduction studies ...

Diabetes-induced testicular cell death is due predominantly to oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor in controlling the antioxidative system and is inducible by sulforaphane (SFN). To test whether SFN prevents diabetes-induced testicular cell death, an insulin-defective stage of type 2 diabetes (IDS-T2DM) was induced in mice. T...

Sulforaphane (SFN) is a natural and highly effective antioxidant. Studies suggest that SFN protects cells and tissues against cadmium (Cd) toxicity. This study investigated the protective effect of SFN against oxidative damage in the testes of Kunming mice exposed to cadmium, and explored the possible molecular mechanisms involved. Cadmium greatly reduced the serum testosterone levels in mice, ...

Sulforaphane (SFN), an isothiocyanate naturally occurring in Cruciferae, induces cytoprotection in several tissues. Its protective effect has been associated with its ability to induce cytoprotective enzymes through an Nrf2-dependent pathway. Gentamicin (GM) is a widely used antibiotic; nephrotoxicity is the main side effect of this compound. In this study, it was investigated if SFN is able to...

Given a set 9 of n points on the plane, a symmerric_furfhesr-neighbor (SFN) pair of points p, q is one such that both p and q are furthest from each other among the points in 8. A pair of points is untipodal if it admits parallel lines of support. In this paper it is shown that a SFN pair of 9 is both a set of extreme points of 9 and an antipodul pair of 8. It is also shown that an asymmerricfu...

Cognitive decline diseases, such as dementia, could be prevented through Cognitive Stimulation (CS). The integration of the members of the elder‟s social family network (SFN) in CS sessions can encourage the elder to perform CS activities. We designed InTouchFun, a pervasive CS collaborative system which eases interaction through natural interfaces and enables SFN members to interact with elder...

BACKGROUND Tissue organization during embryonic development and wound healing depends on the ability of cells on the one hand to exchange adhesive bonds during active rearrangement and on the other to become fixed in place as tissue homeostasis is reached. Cells achieve these contradictory tasks by regulating either cell-cell adhesive bonds, mediated by cadherins, or cell-extracellular matrix (...

Sulforaphane (SFN), a prominent isothiocyanate present in cruciferous vegetables, is believed to be responsible along with other isothiocyanates for the cancer preventive activity of such vegetables. SFN arrests mitosis, possibly by affecting spindle microtubule function. A critical property of microtubules is their rapid and time-sensitive growth and shortening dynamics (dynamic instability), ...

Sarcoidosis is a chronic inflammatory illness and small-fiber neuropathy (SFN) is one of the disabling and often chronic manifestations of the disease. SFN presents with peripheral pain and symptoms of autonomic dysfunction. The character of the pain can be burning or shooting. Besides, allodynia and hyperesthesia can exist. Diagnosis is usually made on the basis of clinical features, in combin...

Uterine fibroids are fibrotic tumors of uterus associated with abnormal menstrual bleeding and pelvic pain or pressure. Our recent data showed that Hippo signaling was dysregulated (OFF) in uterine influenced by extracellular matrix (ECM) stiffness. When is ‘OFF’, the downstream effectors, YAP/TAZ, interact TEAD to induce transcription genes involved cell growth fibrosis. Sulforaphane (SFN) an ...