Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy. We recently provided a novel perspective on the mechanisms of this symptom by showing that a simple switch in trigeminal glycine synaptic inhibition can turn touch into pain by unmasking innocuous input to superficial dorsal horn nociceptive specific neurons t...

Cone signals divide into parallel ON and OFF bipolar cell pathways, which respond to objects brighter or darker than the background and release glutamate onto the corresponding type of ganglion cell. It is assumed that ganglion cell excitatory responses are driven by these bipolar cell synapses. Here, we report an additional mechanism: OFF ganglion cells were driven in part by the removal of sy...

1 Title: 2 Adrenergic receptor-mediated disinhibition of mitral cells triggers long-term enhancement of 3 synchronized oscillations in the olfactory bulb. 4 5 Authors: 6 Sruthi Pandipati, David H. Gire, Nathan E. Schoppa 7 8 Affiliations: 9 1 Neuroscience Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 10 2 Medical Scientist Training Program, University of Colorado, Anschut...

This study applied online disinhibition effect [1] to examine perceived psychological benefits (PPB) derived from computer-mediated communication (CMC). The models examined the relationship between psychological health (loneliness, self-esteem and social anxiety) and CMC for social interaction (to seek romantic/sexual relationships and emotional/social support), compulsive internet use (CIU) an...

Although research has been conducted on the course, consequences, and correlates of borderline personality disorder (BPD), little is known about its emergence in childhood, and no studies have examined the extent to which theoretical models of the pathogenesis of BPD in adults are applicable to the correlates of borderline personality symptoms in children. The goal of this study was to examine ...

BACKGROUND Hypersexuality is defined as an increase in libido. It is often confounded with sexual disinhibition and inappropriate sexual behavior directed against oneself or against others. It is described in 2.9 to 8% of patients living at home and in 3.8 to 7% of patients in institutions. The pathophysiology of hypersexuality is complex. Several brain areas are involved. The psychological fac...

Olfaction exerts a profound influence on reproductive physiology and behavior in many animals, including rodents. Odors are recognized by sensory neurons residing in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) in mice and many other vertebrates. The relative contributions of the MOE and VNO in the display of female behaviors are not well understood. Mice null for Cnga2 o...