Sex chromosomes are uniquely subject to chromosome-wide silencing during male meiosis, and silencing persists into post-meiotic spermatids. Against this background, a select set of sex chromosome-linked genes escapes silencing and is activated in post-meiotic spermatids. Here, we identify a novel mechanism that regulates escape gene activation in an environment of chromosome-wide silencing in m...

Voluntary exercise has proved to be an effective therapeutic tool improve cardiac function in aged rats with clearly visible sex differences. Long-term is associated decreased Ogn and Comt expression enhanced presence of Pcp4 Esm1 genes. Sex-dependent changes were also observed the cardiovascular key proteins. Fundamental alterations gene protein may contribute improvement performance.

This study focused on three questions: Is there a difference in men's and women's diabetes attitudes? Do health professionals give different recommendations to men and women? Is there a difference between men and women in care adherence? A total of 1201 patients with diabetes were surveyed; 65% of these patients were women. Differences in diabetes attitudes (three of seven attitudes) were most ...

OBJECTIVE The incidence of Type 1 diabetes mellitus (T1DM) in Greek-Cypriot children aged less than 15 years between 1990 and 2009 was examined along with gender differences concerning the age of onset and the seasonal variation at manifestation of the disease. DESIGN All newly diagnosed cases of T1DM in children less than 15 years old were registered with the capture-recapture method from 19...

Sex-dependent differences in xenobiotic metabolism are most pronounced in rats. Consequently, this species quickly became the most popular animal model to study sexual dimorphisms in xenobiotic metabolism. Exaggerated sex-dependent variations in metabolism by rats may be the result of extensive inbreeding or differential evolution of cytochrome P450 (CYP) isoforms in mammals. Sex-dependent diff...

Sex-dependent selection can help maintain sexual dimorphism. When the magnitude of selection exerted on a heritable sex trait differs between the sexes, it may prevent each sex to reach its phenotypic optimum. As a consequence, the benefit of expressing a sex trait to a given value may differ between males and females favouring sex-specific adaptations associated with different values of a sex ...