Patients' knowledge about psoriasis and its treatment has been randomly studied previously. The aim of the study is to investigate patients' knowledge about psoriasis in relation to undergoing patient education in the context of climate therapy (CT). The psoriasis knowledge questionnaire (PKQ) was used in a follow-up pre-post study design of Norwegian patients with psoriasis at the age of 20 ye...

Accumulating evidence indicates that body weight, alcohol and smoking are associated with psoriasis. However, these factors have scarcely been investigated in relation to onset and disease activity at onset of psoriasis. A population-based case-control study was performed including 373 cases with onset of first-time plaque psoriasis within 12 months and matched healthy controls. Psoriasis activ...

Abstract Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferation in the skin. Dysregulation of immune system an important factor this pathology. Inflammation markers, pro-inflammatory cytokines, cells are reported to be changed psoriasis. Study design In current cohort study, possible changes interleukin-6 (IL-6), neopterin levels, kynurenine (Kyn) pat...

Abstract Background Information is lacking from real‐life studies evaluating the efficacy of tildrakizumab in moderate‐to‐severe psoriasis. Materials and Methods We retrospectively analysed a database 30 patients with psoriasis (PsO) that were treated (100 mg, s.c.) followed for 36 weeks. Clinical (disease severity treatment response) was evaluated by Psoriasis Area Severity Index (PASI) at bas...

Background The phase III reSURFACE 1 and 2 (NCT01722331/NCT01729754) trials of the anti-interleukin-23p19 monoclonal antibody tildrakizumab (TIL) for psoriasis treatment are complete. Objectives We present 5-year pooled data from 2. Methods were double-blind, randomized, controlled studies with optional long-term extensions. Adults moderate-to-severe chronic plaque randomized : to TIL 100 mg (T...

Background: Psoriasis is a chronic auto-inflammatory condition. Treatment modalities include methotrexate (MTX) and apremilast (APL). Although the efficacy of MTX APL well studied, evidence their superiority one over other lacking. Dermoscopy helpful in diagnosis treatment evaluation. Therefore, dermoscopy utilized to assess response. Objectives: This study aimed evaluate dermoscopic assessment...

Introduction: Plantar psoriasis is a variant of and accounts for 3–4% total cases psoriasis. Psoriasis, an autoimmune chronic inflammatory disease the skin, can leave patient in agony with its distressing infection episodes. The homoeopathic system medicine offers wide range medicines that have beneficial role managing as depicted previous studies. Case summary: A distinct case plantar treated ...

BACKGROUND Matrix metalloproteinases (MMPs), which show a significant ability to cleave the components of extracellular matrix, and tissue inhibitors of metalloproteinases (TIMPs), which slow down the activity of those enzymes, may be implicated in the pathogenesis and spread of psoriatic disease. This study aims to analyze plasma levels of MMP-2 and TIMP-2 in plaque psoriasis patients before a...

Unlike ultraviolet radiation, blue light (380 nm to 500 nm) is non-ionizing representing a potentially safer and more accessible phototherapeutic modality. We investigated the feasibility, tolerability, early efficacy of whole-body for treatment psoriasis vulgaris Grover’s disease in single-arm, prospective, open-label clinical study. A total 11 patients with (mean baseline lesion count 27.4) 9...

Introduction Brodalumab is a monoclonal antibody that targets the subunit A of interleukin-17A receptor (IL17RA), inhibiting signaling various isoforms IL-17 family. It has been approved for treatment moderate-to-severe plaque psoriasis after being evaluated in three Phase-3 trials. However, long-term data on brodalumab real-life setting are still limited. Methods The aim this study was to eval...